ArticlePediatric nephrology (Berlin, Germany)2008
Prediction of high-degree steroid dependency in pediatric idiopathic nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878914 (A Multinational Prospective Study on the Duration of Steroid Therapy in Steroid Sensitive Nephrotic Syndrome), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multinational Prospective Study on the Duration of Steroid Therapy in Steroid Sensitive Nephrotic Syndrome
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Single relapse at ≥ 0.5 mg/kg alternate-day prednisone predicts course of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Time to remission in childhood steroid sensitive nephrotic syndrome: a change in perspective.European journal of pediatrics · 2025Article
- Steroid pulse therapy in idiopathic nephrotic syndrome in the era of modern immunosuppressive treatment-still up to date?Pediatric nephrology (Berlin, Germany) · 2025Article
- Necessity of cyclosporine for minimal change disease with transient remission during initial 4-week prednisolone treatment: is it steroid-sensitive or steroid-resistant nephrotic syndrome?Pediatric nephrology (Berlin, Germany) · 2025Article
- Timing of relapse as a key indicator of steroid-sparing requirements in childhood idiopathic nephrotic syndrome.Journal of nephrology · 2024Article
- Association between the time of initial relapse and subsequent relapses in patients with childhood-onset idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2024Article
- Childhood Idiopathic Nephrotic Syndrome: Does the Initial Steroid Treatment Modify the Outcome? A Multicentre, Prospective Cohort Study.Frontiers in pediatrics · 2021Article
- Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience.Singapore medical journal · 2020Article
- Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome.Kidney international reports · 2020Article
- Predictors of frequent relapsing and steroid-dependent nephrotic syndrome in children.Turk pediatri arsivi · 2018Article
- Predictive risk factors of steroid dependent nephrotic syndrome in children.Journal of nephropathology · 2017Article
- Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis.Italian journal of pediatrics · 2015Review
- Predictors of remission and relapse in idiopathic nephrotic syndrome: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2014Article
- Prediction of steroid-sparing agent use in childhood idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2013Article
- Chapter 3: Steroid-sensitive nephrotic syndrome in children.Kidney international supplements · 2012Article
- Early identification of steroid dependency in Japanese children with steroid-sensitive nephrotic syndrome undergoing short-term initial steroid therapy.Pediatric nephrology (Berlin, Germany) · 2011Article
- Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2010Article
- Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most patients with idiopathic nephrotic syndrome are steroid-responsive, but about 50% relapse and often become steroid-dependent and exposed to long-term steroid complications. The aim of this study was to determine predictive risk factors for steroid and/or cyclosporine A (CyA) dependence. In France, steroid responsiveness is defined as remission after 1 month of oral prednisone (60 mg/m(2) per day) and-in the case of persistent proteinuria on day 30-three methylprednisolone pulses (MPP; 1 g/1.73 m(2) on days 1, 3, and 5). Thirty-five steroid-responsive children, followed between 1999 and 2006, were included in this study. Median age at diagnosis was 4.9 years. All patients initially received prednisone 60 mg/m(2) per day. Twenty-four of the 35 patients were steroid-dependent, with 12 requiring MPP. Of the latter 12 patients, 83.3% were treated with CyA during follow-up; in comparison, only 16.7% of the patients who did not receive MPP required CyA during follow-up (chi-square test, P = 0.001). T risk for steroid dependence was 100% in our cohort if remission was achieved after day 20. Patients who need MPP are at high risk to require CyA to achieve disease control. By identifying these children, we could use adequate immunosuppressive drugs earlier and reduce morbidity related to steroids and multiple relapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.