Evidence map›Paper›PMID 18618105›Full record

ArticleImmunogenetics2008

A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin.

Nel Otting, Corrine M C Heijmans, Marit van der Wiel, Natasja G de Groot, Gaby G M Doxiadis, Ronald E Bontrop

Open access · hybridAbstract read
In one paragraph

Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

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  17. Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nel OttingDepartment of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands. otting@bprc.nl
Corrine M C Heijmans
Marit van der Wiel
Natasja G de Groot
Gaby G M Doxiadis
Ronald E Bontrop
Biomedical Primate Research Centre · NL

Funding

MHC TYPING OF MACAQUES USED IN AIDS RESEARCHR24RR016038 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 2001 to 2011
$6.3M
NCRR NIH HHS 1-R24-RR16038-01NCRR NIH HHS R24 RR016038
6 · The paper itself

Abstract

The major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu-B gene copy number variation, and the sum of expressed genes varies among haplotypes. In addition, these genes display differential transcription levels. The majority of the Mamu-B alleles discovered during this investigation appear to be unique for the population studied. Only one particular Mamu-B haplotype is shared between Indian and Chinese animals, and it must have been present in the progenitor stock. Hence, the data highlight the fact that most allelic polymorphism, and most of the Mamu-B haplotypes themselves, are of relatively recent origin and were most likely generated after the separation of the Indian and Chinese rhesus macaque populations.

Indexed as

Genes, MHC Class IPolymorphism, GeneticAllelesAnimalsChinaHaplotypesMacaca mulatta

Identifiers

PMID18618105
PMCPMC2491420
OpenAlexW2039616624

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.