ArticleCell death and differentiation2008
Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death.
Article in Cell death and differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.Cell communication and signaling : CCS · 2025Article
- A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.Immunological reviews · 2020Review
- Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy.Journal of the American Heart Association · 2018Article
- Glycolysis promotes caspase-3 activation in lipid rafts in T cells.Cell death & disease · 2018Article
- Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress.PloS one · 2015Article
- Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.Immunity · 2014Article
- Exploring the elasticity and adhesion behavior of cardiac fibroblasts by atomic force microscopy indentation.Materials science & engineering. C, Materials for biological applications · 2014Article
- IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3.Cell death and differentiation · 2014Article
- Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.Cell death & disease · 2013Article
- Pin1-FADD interactions regulate Fas-mediated apoptosis in activated eosinophils.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis.Cell death and differentiation · 2013Article
- Article
- Caspase work model during pathogen infection.Virologica Sinica · 2011Review
- Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death.Human immunology · 2011Article
- RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.Molecular cell · 2011Review
- Lipid rafts in mast cell biology.Journal of lipids · 2011Article
- Regulation of NF-κB signaling by caspases and MALT1 paracaspase.Cell research · 2011Review
- Cell death.The New England journal of medicine · 2009Review
- Cytoskeleton-membrane interactions in membrane raft structure.Cellular and molecular life sciences : CMLS · 2009Review
- CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling.The Journal of experimental medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Caspase-8, a cysteine-protease, initiates apoptosis when activated by death receptors. Caspase-8 is also essential for initiating T lymphocyte proliferation following T-cell antigen receptor (TCR) signaling. Given these disparate functions of caspase-8, we sought to determine whether this represented only a difference in the magnitude of caspase-8 activation, or different intracellular locations of active caspase-8. We demonstrate by high-resolution multicolor confocal laser scanning microscopy an aggregation of active caspase-8 within membrane lipid rafts in T cells stimulated with anti-CD3. This suggests that following TCR stimulation active caspase-8 physically interacts with lipid raft proteins, possibly to form a signaling platform. In contrast, Fas stimulation of T cells resulted in a much more profound activation of caspase-8 that was exclusively cytosolic. These confocal microscopic findings were confirmed using discontinuous sucrose gradient ultracentrifugation to isolate lipid raft versus cytosolic components. This sequestration model of caspase-8 activation was further supported by the observation that a classic caspase-8 substrate, BID, was not cleaved in CD3-stimulated T cells, but was cleaved after Fas engagement. Our data support a model that the location of active caspase-8 may profoundly influence its functional capacity as a regulator of either cell cycling or cell death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.