ArticleArteriosclerosis, thrombosis, and vascular biology2008
Longitudinal change in serum gamma-glutamyltransferase and cardiovascular disease mortality: a prospective population-based study in 76,113 Austrian adults.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Association between the levels of gamma-glutamyl transpeptidase and the risk of stroke: systematic review and meta-analysis.Arquivos de neuro-psiquiatria · 2025Pooled it
- Trial
- A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.Journal of cardiovascular translational research · 2026Review
- Association between serum gamma-glutamyltransferase and stroke in adults from national health and nutrition examination survey (2005-2016): a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Can Serum Gamma-Glutamyl Transferase Predict All-Cause Mortality in Hypertensive Patients?Cureus · 2024Article
- γ-Glutamyl Transferase and Long-Term Survival in the SYNTAXES Trial: Is It Just the Liver?Journal of the American Heart Association · 2024Article
- Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study.Biomolecules · 2023Article
- Gamma-glutamyl transferase and risk of all-cause and disease-specific mortality: a nationwide cohort study.Scientific reports · 2023Article
- A Resourceful Race: Bacterial Scavenging of Host Sulfur Metabolism during Colonization.Infection and immunity · 2022Review
- Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review.BMC medical research methodology · 2021Article
- Association of LDLR rs1433099 with the Risk of NAFLD and CVD in Chinese Han Population.Journal of clinical and translational hepatology · 2021Article
- Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk.Journal of human hypertension · 2021Article
- Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study.World journal of gastroenterology · 2021Article
- Association of gamma-glutamyl transferase with subclinical coronary atherosclerosis and cardiac outcomes in non-alcoholics.Scientific reports · 2020Article
- Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension.Frontiers in cardiovascular medicine · 2020Article
- Effects of Gamma-Glutamyl Transferase on Stroke Occurrence Mediated by Atrial Fibrillation.Journal of clinical neurology (Seoul, Korea) · 2020Article
- γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2019Article
- Long-term risk for end-stage kidney disease and death in a large population-based cohort.Scientific reports · 2018Article
- Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveThe purpose of this study was to investigate the association of longitudinal change in serum gamma-glutamyltransferase (GGT) with mortality from cardiovascular disease (CVD). METHODS AND
resultsA population-based cohort of 76,113 Austrian men and women with 455,331 serial GGT measurements was prospectively followed-up for a median of 10.2 years after assessment of longitudinal GGT change during an average period of 6.9 years. Cox proportional hazards regression with time-varying covariates was used to evaluate GGT change as an independent predictor for CVD death. Independently of baseline GGT and other classical CVD risk factors, a pronounced increase in GGT (7-year change >9.2 U/L) was significantly associated with increased total CVD mortality in men (P=0.005); the adjusted hazard ratio (95% confidence interval) in comparison to stable GGT (7-year change -0.7 to 1.3 U/L) was 1.40 (1.09 to 1.81). Similarly, total CVD risk was elevated for increasing GGT in women, although effects were less pronounced and statistically significant only in subanalyses regarding coronary heart disease. Age of participants significantly modified the relation between GGT change and CVD mortality, with markedly stronger associations to be observable for younger individuals.
conclusionsOur study is the first to demonstrate that a longitudinal increase in GGT, independently of baseline GGT and even within its normal range, significantly increases risk of fatal CVD.
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