ArticleAmerican journal of respiratory and critical care medicine2008
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.Scientific reports · 2022Pooled it
- ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Pooled it
- Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.American journal of respiratory and critical care medicine · 2011Trial
- IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026Article
- Gene Polymorphisms Associated with Treatment Response of Asthma in Chinese Children.Journal of asthma and allergy · 2026Article
- STING-dependent induction of neutrophilic asthma exacerbation in response to house dust mite.Allergy · 2025Article
- Circulating microRNAs associated with bronchodilator response in childhood asthma.BMC pulmonary medicine · 2024Article
- CLCA1 and BPIFB1 are potential novel biomarkers for asthma: an iTRAQ analysis.Journal of thoracic disease · 2024Article
- Heterogeneity of Treatment Response to Asthma.Advances in experimental medicine and biology · 2023Article
- Review
- Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.Nature communications · 2022Article
- A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.ERJ open research · 2022Article
- An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.Science immunology · 2022Article
- Beyond eNOS: Genetic influence in NO pathway affecting drug response.Genetics and molecular biology · 2022Article
- Pharmacogenetics of Bronchodilator Response: Future Directions.Current allergy and asthma reports · 2021Review
- Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.European journal of clinical pharmacology · 2021Article
- The Role of SNP Interactions when Determining Independence of Novel Signals in Genetic Association Studies-An Application toJournal of personalized medicine · 2021Article
- Age by Single Nucleotide Polymorphism Interactions on Bronchodilator Response in Asthmatics.Journal of personalized medicine · 2021Article
- Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children.The Journal of allergy and clinical immunology · 2020Article
- Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
rationaleInhaled beta-agonists are one of the most widely used classes of drugs for the treatment of asthma. However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients.
objectivesTo screen variants in candidate genes in the steroid and beta-adrenergic pathways for association with response to inhaled beta-agonists.
methodsWe genotyped 844 single nucleotide polymorphisms (SNPs) in 111 candidate genes in 209 children and their parents participating in the Childhood Asthma Management Program. We screened the association of these SNPs with acute response to inhaled beta-agonists (bronchodilator response [BDR]) using a novel algorithm implemented in a family-based association test that ranked SNPs in order of statistical power. Genes that had SNPs with median power in the highest quartile were then taken for replication analyses in three other asthma cohorts. MEASUREMENTS AND MAIN
resultsWe identified 17 genes from the screening algorithm and genotyped 99 SNPs from these genes in a second population of patients with asthma. We then genotyped 63 SNPs from four genes with significant associations with BDR, for replication in a third and fourth population of patients with asthma. Evidence for association from the four asthma cohorts was combined, and SNPs from ARG1 were significantly associated with BDR. SNP rs2781659 survived Bonferroni correction for multiple testing (combined P value = 0.00048, adjusted P value = 0.047).
conclusionsThese findings identify ARG1 as a novel gene for acute BDR in both children and adults with asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.