ArticleEndocrinology2008
Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Role of Gonadal Steroid Hormones in the Eye: Therapeutic Implications.Biomolecules · 2024Review
- Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.American journal of physiology. Heart and circulatory physiology · 2017Article
- Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies.Expert opinion on therapeutic targets · 2016Review
- Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats.Psychopharmacology · 2014Article
- Novel progesterone receptors: neural localization and possible functions.Frontiers in neuroscience · 2013Review
- Non-genomic mechanisms of progesterone action in the brain.Frontiers in neuroscience · 2013Review
- Membrane progestin receptors in the midbrain ventral tegmental area are required for progesterone-facilitated lordosis of rats.Hormones and behavior · 2013Article
- Progesterone-induced neuroprotection: factors that may predict therapeutic efficacy.Brain research · 2013Review
- Progesterone and neuroprotection.Hormones and behavior · 2013Review
- Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling.Endocrinology · 2012Article
- Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain.Endocrinology · 2012Article
- Convergence of multiple mechanisms of steroid hormone action.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Progesterone signaling mechanisms in brain and behavior.Frontiers in endocrinology · 2012Article
- Neural progestin receptors and female sexual behavior.Neuroendocrinology · 2012Review
- Novel substrates for, and sources of, progestogens for reproduction.Journal of neuroendocrinology · 2011Review
- Article
- Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications.Steroids · 2011Review
- Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmitters.Frontiers in neuroendocrinology · 2010Review
- Gene expression profiles of intracellular and membrane progesterone receptor isoforms in the mediobasal hypothalamus during pro-oestrus.Journal of neuroendocrinology · 2009Article
- Dopamine agonist signalling in the hypothalamus of female rats is independent of calcium-dependent kinases.Journal of neuroendocrinology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In addition to the activation of classical progestin receptor-dependent genomic pathway, progesterone (P) can activate nonclassical, membrane-initiated signaling pathways in the brain. We recently demonstrated rapid P activation of second-messenger kinases, protein kinase A, and protein kinase C in the ventromedial nucleus (VMN) and preoptic area (POA) of rat brain. To determine whether P can activate yet another Ca+2 dependent kinase, we examined the rapid P modulation of calcium and calmodulin-dependent protein kinase II (CaMKII) in the VMN and POA in female rats. A rapid P-initiated activation of CaMKII basal activity was observed in the VMN but not the POA at 30 min. Estradiol benzoate (EB) priming enhanced this CaMKII basal activity in both the VMN and POA. CaMKII protein levels and phosphorylation of Thr-286 moiety on CaMKII, however, remained unchanged with EB and/or P treatments, suggesting that the changes in the CaMKII kinase activity are due to rapid P modulation of the kinase activity and not its synthesis or autoactivation. Furthermore, intracerebroventricular (icv) administration of a CaMKII-specific inhibitor, KN-93, 30 min prior to the P infusion, in EB-primed, ovariectomized female rats inhibited CaMKII activation but not protein kinase A and protein kinase C activities. Interestingly, icv administration of KN-93 30 min prior to P infusion (icv) resulted in a reduction but not total inhibition of P-facilitated lordosis response in EB-primed female rats. These observations suggest a redundancy or, alternately, a hierarchy in the P-regulated activation of kinase signaling cascades in female reproductive behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.