ArticleThe Journal of physiology2008
Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training.Cardiovascular research · 2023Article
- Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release.iScience · 2023Article
- Transformation of Our Understanding of Breathing Control by Molecular Tools.Annual review of physiology · 2023Review
- Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle.Nature communications · 2020Article
- The effect of general anaesthetics on brain lactate release.European journal of pharmacology · 2020Article
- Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure.JACC. Basic to translational science · 2020Article
- Astrocytes Modulate Baroreflex Sensitivity at the Level of the Nucleus of the Solitary Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).Frontiers in human neuroscience · 2020Review
- Inhibition of glial glutamate transporter GLT1 in the nucleus of the solitary tract attenuates baroreflex control of sympathetic nerve activity and heart rate.Physiological reports · 2018Article
- Review
- Airway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmission.Physiological reports · 2018Article
- Modeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations.Journal of neurophysiology · 2017Article
- Hemichannel-mediated release of lactate.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats.Journal of negative results in biomedicine · 2016Article
- A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe.The Journal of physiology · 2014Article
- The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities.Frontiers in physiology · 2014Review
- ATP metabolism in skeletal muscle arterioles.Physiological reports · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The Breuer-Hering inflation reflex is initiated by activation of the slowly adapting pulmonary stretch receptor afferents (SARs), which monosynaptically activate second-order relay neurones in the dorsal medullary nucleus of the solitary tract (NTS). Here we demonstrate that during lung inflation SARs release both ATP and glutamate from their central terminals to activate these NTS neurones. In anaesthetized and artificially ventilated rats, ATP- and glutamate-selective microelectrode biosensors placed in the NTS detected rhythmic release of both transmitters phase-locked to lung inflation. This release of ATP and glutamate was independent of the centrally generated respiratory rhythm and could be reversibly abolished during the blockade of the afferent transmission in the vagus nerve by topical application of local anaesthetic. Microionophoretic application of ATP increased the activity of all tested NTS second-order relay neurones which receive monosynaptic inputs from the SARs. Unilateral microinjection of ATP into the NTS site where pulmonary stretch receptor afferents terminate produced central apnoea, mimicking the effect of lung inflation. Application of P2 and glutamate receptor antagonists (pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic acid, suramin and kynurenic acid) significantly decreased baseline lung inflation-induced firing of the second-order relay neurones. These data demonstrate that ATP and glutamate are released in the NTS from the central terminals of the lung stretch receptor afferents, activate the second-order relay neurones and hence mediate the key respiratory reflex - the Breuer-Hering inflation reflex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.