ArticleGastroenterology2008
The impact of hospital-acquired infection on outcome in acute pancreatitis.
Article in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- Predictive factors at emergency department admission for a complicated course of acute pancreatitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review.Antibiotics (Basel, Switzerland) · 2024Article
- Review
- Characteristics and risk factors for extrapancreatic infection in patients with moderate or severe acute pancreatitis.Heliyon · 2023Article
- A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection.Frontiers in cellular and infection microbiology · 2022Article
- Heparin-binding protein is significantly increased in acute pancreatitis.BMC gastroenterology · 2021Article
- The impacts of infectious complications on outcomes in acute pancreatitis: a retrospective study.Military Medical Research · 2020Article
- Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients.BMC gastroenterology · 2020Article
- Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.Frontiers in cellular and infection microbiology · 2020Review
- Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis.World journal of gastroenterology · 2019Article
- Increased Mortality from Extrapancreatic Infections in Hospitalized Patients with Acute Pancreatitis.Gastroenterology research and practice · 2019Article
- ADAM17-Mediated Reduction in CD14Frontiers in immunology · 2019Article
- [Diagnosis and stage-adapted treatment of acute pancreatitis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Article
- Extra-pancreatic complications, especially hemodialysis predict mortality and length of stay, in ICU patients admitted with acute pancreatitis.Gastroenterology report · 2018Article
- Recent advances in understanding and managing acute pancreatitis.F1000Research · 2018Review
- The role of multidisciplinary meetings for benign pancreatobiliary diseases: a tertiary centre experience.Frontline gastroenterology · 2017Article
- Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus.Therapeutics and clinical risk management · 2017Article
- Acute Pancreatitis.The New England journal of medicine · 2016Review
- Management of acute pancreatitis (AP) - Polish Pancreatic Club recommendations.Przeglad gastroenterologiczny · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsLittle is known regarding the impact of hospital-acquired infection (HAI) in acute pancreatitis (AP). We conducted a population-based assessment of the impact of HAI on outcome in AP.
methodsPatient data were obtained from the Cardinal Health Clinical Outcomes Research Database, a large population-based data set. Cases with principal diagnosis by International Classification of Diseases, ninth revision, clinical modification 577.0 (AP) between January 2004 and January 2005 were identified. These cases were linked with recently reported HAI data collected by the Pennsylvania Health Care Cost Containment Council. Identification of HAI was based on definitions set forth by the National Nosocomial Infection Surveillance System. We conducted a 5:1 multivariate propensity-matched cohort study to determine the independent contribution of HAI to in-hospital mortality, length of stay (LOS), and hospital charges.
resultsFrom 177 participating hospitals, there were 11,046 AP cases identified. Eighty-two (0.7%) patients developed an HAI. Mortality in the overall AP population was 1.2% vs 11.4% among 405 matched non-HAI controls vs 28.4% among patients who developed HAI (chi(2) test, P < .0001). Fifteen percent of all deaths was associated with an HAI. Both average LOS and hospital charges were significantly increased among patients with HAI compared with matched non-HAI controls.
conclusionsWe determined that HAI had a major impact on mortality in AP. Patients who developed HAI also had significantly increased LOS and hospital charges. These differences were not explained by increased disease severity alone. Reducing HAI is an important step to improving outcome in AP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.