Trial reportCanadian journal of psychiatry. Revue canadienne de psychiatrie2008
Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy.
Trial report in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychological interventions for antisocial personality disorder.The Cochrane database of systematic reviews · 2020Pooled it
- Psychological interventions for antisocial personality disorder.The Cochrane database of systematic reviews · 2010Pooled it
- Trial
- Perceived Social Support and Interpersonal Functioning as Predictors of Treatment Response Among Depressed Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Clinical Outcome Evaluations and CBT Response Prediction in Myotonic Dystrophy.Journal of neuromuscular diseases · 2021Trial
- Trial
- The desire to belong: Social identification as a predictor of treatment outcome in social anxiety disorder.Behaviour research and therapy · 2016Trial
- One-Year Follow-Up of the Effectiveness of Cognitive Behavioral Group Therapy for Patients' Depression: A Randomized, Single-Blinded, Controlled Study.TheScientificWorldJournal · 2015Trial
- Thin slice ratings of client characteristics in intake assessments: predicting symptom change and dropout in cognitive therapy for depression.Behaviour research and therapy · 2013Trial
- Trial
- Personality change during depression treatment: a placebo-controlled trial.Archives of general psychiatry · 2009Trial
- Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Assessing Temperament Risk Factors in Late Childhood and Early Adolescence: Development and Validation of the Integrative Late Childhood Temperament Inventory.Child psychiatry and human development · 2026Article
- Interactive dynamic modulation of antidepressant treatment response by serum interleukin-1β and Neuroticism at 12 weeks.Scientific reports · 2026Article
- Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation.Psychopharmacology · 2025Article
- Personality traits among major depressive disorder in southern Thailand: a hospital-based case-control study.BMC psychology · 2023Article
- Engineering Virtuous health habits using Emotion and Neurocognition: Flexibility for Lifestyle Optimization and Weight management (EVEN FLOW).Frontiers in aging neuroscience · 2023Review
- The Effectiveness of Mindfulness-Based Cognitive Therapy in Primary Care and the Role of Depression Severity and Treatment Attendance.Mindfulness · 2022Article
- Stressful life events and openness to experience: Relevance to depression.Journal of affective disorders · 2021Article
- Personality changes with subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression.Journal of psychiatry & neuroscience : JPN · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveEffective treatments for major depressive disorder exist, yet some patients fail to respond, or achieve only partial response. One approach to optimizing treatment success is to identify which patients are more likely to respond best to which treatments. The objective of this investigation was to determine if patient personality characteristics are predictive of response to either cognitive-behavioural therapy (CBT) or pharmacotherapy (PHT).
methodDepressed patients completed the Revised NEO Personality Inventory, which measures the higher-order domain and lower-order facet traits of the Five-Factor Model of Personality, and were randomized to receive either CBT or PHT.
resultFour personality traits--the higher-order domain neuroticism and 3 lower-order facet traits: trust, straightforwardness, and tendermindedness--were able to distinguish a differential response rate to CBT, compared with PHT.
conclusionThe assessment of patient dimensional personality traits can assist in the selection and optimization of treatment response for depressed patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.