ArticleCell proliferation2008
Identification of osteo-adipo progenitor cells in fat tissue.
Article in Cell proliferation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Icariin and Icariside II Reciprocally Stimulate Osteogenesis and Inhibit Adipogenesis of Multipotential Stromal Cells through ERK Signaling.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells.Drug design, development and therapy · 2019Article
- SeesawPred: A Web Application for Predicting Cell-fate Determinants in Cell Differentiation.Scientific reports · 2018Article
- Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst.PLoS computational biology · 2017Article
- A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers.Stem cell reports · 2016Article
- Association of the I264T variant in the sulfide quinone reductase-like (SQRDL) gene with osteoporosis in Korean postmenopausal women.PloS one · 2015Article
- The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose-derived stem cells.Tissue engineering. Part B, Reviews · 2014Review
- Adult stem cells properties in terms of commitment, aging and biological safety of grit-blasted and Acid-etched ti dental implants surfaces.International journal of molecular and cellular medicine · 2014Article
- Article
- BMP4 promotes vascularization of human adipose stromal cells and endothelial cells in vitro and in vivo.Cell proliferation · 2013Article
- Low-intensity pulsed ultrasound induced enhanced adipogenesis of adipose-derived stem cells.Cell proliferation · 2013Article
- Article
- Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.The British journal of nutrition · 2012Article
- Secreted factors from adipose tissue increase adipogenic differentiation of mesenchymal stem cells.Cell proliferation · 2012Article
- Mechanical stretch inhibits adipogenesis and stimulates osteogenesis of adipose stem cells.Cell proliferation · 2012Article
- Native human adipose stromal cells: localization, morphology and phenotype.International journal of obesity (2005) · 2011Article
- Adipose-derived stem cells for clinical applications: a review.Cell proliferation · 2011Review
- Protein Expression of STRO-1 Cells in Response to Different Topographic Features.Journal of tissue engineering · 2011Article
- Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway.Archives of medical science : AMS · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn this study, a group of cells that expressed both osteogenic and adipogenic characters was identified from murine adipose stromal cells. MATERIALS AND
methodsThese cells could be enriched in the Sca-1-1 population and express both osteogenic and adipogenic genes. Osteogenic induction enhanced expression of osteogenic genes and inhibited expression of adipogenic genes, while adipogenic induction enhanced expression of adipogenic genes and inhibited expression of osteogenic genes. These cells have been called osteo-adipo progenitors (OAPs).
resultsOAPs expressed transcription factor runt-related transcription factor 2 (RUNX2) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) proteins in cytoplasm. When OAPs were cultured in adipogenic medium, PPAR-gamma moved to the nucleus and the cells differentiated into adipocytes, while the RUNX2 remained in the cytoplasm. In contrast, when OAPs were cultured in osteogenic medium, RUNX2 moved to the nucleus and the cells differentiated to osteocytes, while the PPAR-gamma remained in the cytoplasm.
conclusionsThese experiments suggest that osteoblasts and adipocytes share a common predecessor, the OAP, in murine adipose stromal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.