ArticleThe Journal of organic chemistry2008
Bio-orthogonal phosphatidylserine conjugates for delivery and imaging applications.
Article in The Journal of organic chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Status and Challenges of Blue OLEDs: A Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast.ACS central science · 2020Article
- Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.Cell chemical biology · 2019Article
- Emerging methodologies to investigate lipid-protein interactions.Integrative biology : quantitative biosciences from nano to macro · 2012Review
- Evaluation of fluorescent phosphatidylserine substrates for the aminophospholipid flippase in mammalian cells.Journal of fluorescence · 2012Article
- Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis.Journal of the American Chemical Society · 2011Article
- Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.Bioconjugate chemistry · 2010Article
- Modular synthesis of biologically active phosphatidic acid probes using click chemistry.Molecular bioSystems · 2009Article
- Lipid binding domains: more than simple lipid effectors.Journal of lipid research · 2009Review
- Membrane transporters for anions that use a relay mechanism.Journal of the American Chemical Society · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The syntheses of phosphatidylserine (PS) conjugates are described, including fluorescent derivatives for potential cellular delivery and bioimaging applications. Installation of terminal functional groups (amine, thiol, or alkyne) onto the sn-2 chain provides reactive sites for bio-orthogonal conjugation of cargo with suitably protected PS derivatives. An amine-containing PS forms amide bonds with peptidic cargo, a thiol derivative is designed for conjugation to cargo that contain alpha-halo carbonyls or Michael acceptors, and the terminal alkyne PS analogue permits "click" conjugation with any azide-tagged molecule. This latter conjugation method is quite versatile as it can be performed without PS headgroup protection, in aqueous media, and with acid-labile cargo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.