Evidence map›Paper›PMID 18615590›Full record

ReviewJournal of cellular biochemistry2008

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer.

Gary S Stein, Sayyed K Zaidi, Janet L Stein, Jane B Lian, Andre J van Wijnen, Martin Montecino, Daniel W Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi and 3 more

Abstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Episensitization: Defying Time's Arrow.Frontiers in oncology · 2015
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gary S SteinDepartment of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. gary.stein@umassmed.edu
Sayyed K Zaidi
Janet L Stein
Jane B Lian
Andre J van Wijnen
Martin Montecino
Daniel W Young
Amjad Javed
Jitesh Pratap
Je-Yong Choi
Syed A Ali
Sandhya Pande
Mohammad Q Hassan

Funding

SUBNUCLEAR TARGETING OF TRANSCRIPTION FACTORSP01CA082834 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2001 to 2015
$18.4M
Subnuclear Integration of Regulatory Signals Controlling Bone Cell FunctionP01AR048818 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, JANET L · 2002 to 2011
$14.0M
NCI NIH HHS CA82834NCI NIH HHS P01 CA082834NIAMS NIH HHS AR48818NIAMS NIH HHS P01 AR048818
6 · The paper itself

Abstract

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

Indexed as

Epigenesis, GeneticAnimalsCell NucleusGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansNeoplasmsTranscription FactorsTranscription Factors

Identifiers

PMID18615590
PMCPMC2612589

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.