Evidence map›Paper›PMID 18615232›Full record

ArticleThe journal of nutrition, health & aging

Lower extremity muscle mass predicts functional performance in mobility-limited elders.

K F Reid, E N Naumova, R J Carabello, E M Phillips, R A Fielding

Abstract read
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In one paragraph

Article in The journal of nutrition, health & aging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. The effects of exercise training on hypertensive older adults: an umbrella meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Pooled it
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  9. Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

K F ReidNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
E N Naumova
R J Carabello
E M Phillips
R A Fielding

Funding

YOGA INDUCED CHANGES IN BRAIN GABA LEVELSM01RR000533 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANTMAN, KAREN · 1985 to 2008
$19.4M
LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLYR01AG018844 · NIA · TUFTS UNIVERSITY BOSTON · PI FIELDING, ROGER A. · 2001 to 2009
$3.0M
NCRR NIH HHS M01 RR000533NCRR NIH HHS M01 RR00533NIA NIH HHS AG18844NIA NIH HHS R01 AG018844
6 · The paper itself

Abstract

objectivesThis study examined the influence of lower extremity body composition and muscle strength on the severity of mobility-disability in community-dwelling older adults.

methodsFifty-seven older males and females (age 74.2 +/- 7 yrs; BMI 28.9 +/- 6 kg/m2) underwent an objective assessment of lower extremity functional performance, the Short Physical Performance Battery test (SPPB). Participants were subsequently classified as having moderate (SPPB score 7: n = 38) or severe mobility impairments (SPPB score <or= 7: n = 19). Body composition was assessed using dual-energy X-ray absorptiometry and provided measures of bone mineral density (BMD), total leg lean mass (TLM) and total body fat. Maximal hip extensor muscle strength was estimated using the bilateral leg press exercise. Multiple logistic regression analysis was utilized to identify the significant independent variables that predicted the level of mobility-disability.

resultsTLM was a strong independent predictor of the level of functional impairment, after accounting for chronic medical conditions, BMD, body fat, body weight and habitual physical activity. In a separate predictive model, reduced muscle strength was also a significant predictor of severe functional impairment. The severity of mobility-disability was not influenced by gender (p = 0.71). A strong association was elicited between TLM and muscle strength (r = 0.78, p < 0.01).

conclusionsThese data suggest that lower extremity muscle mass is an important determinant of physical performance among functionally-limited elders. Such findings may have important implications for the design of suitable strategies to maintain independence in older adults with compromised physical functioning. Additional studies are warranted to assess the efficacy of lifestyle, exercise or therapeutic interventions for increasing lean body mass in this population.

Indexed as

Mobility LimitationAbsorptiometry, PhotonActivities of Daily LivingAgedBody CompositionBone DensityCross-Sectional StudiesExercise TestFemaleHealth StatusHumansLogistic ModelsLower ExtremityMaleMuscle, SkeletalMuscle Strength

Identifiers

PMID18615232
PMCPMC2544628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.