ArticlePPAR research2008
A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer Biology.
Article in PPAR research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis.Frontiers in immunology · 2023Article
- Molecular docking of two cytotoxic compounds fromNarra J · 2021Article
- Artesunate ameliorates cigarette smoke-induced airway remodelling via PPAR-γ/TGF-β1/Smad2/3 signalling pathway.Respiratory research · 2021Article
- Article
- Inhalation delivery of Telmisartan enhances intratumoral distribution of nanoparticles in lung cancer models.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Pathway hunting by random survival forests.Bioinformatics (Oxford, England) · 2013Article
- Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation.International journal of biological sciences · 2013Article
- Effect of NDP-α-MSH on PPAR-γ and -β expression and anti-inflammatory cytokine release in rat astrocytes and microglia.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxisome proliferator-activated receptor-gamma (PPARgamma) and retinoic acid X-receptor (RXR) heterodimer, which regulates cell growth and differentiation, represses the TGFbeta1 gene that encodes for the protein involved in cancer biology. This review will introduce the novel mechanism associated with the inhibition of the TGFbeta1 gene by PPARgamma activation, which regulates the dephosphorylation of Zf9 transcription factor. Pharmacological manipulation of TGFbeta1 by PPARgamma activators can be applied for treating TGFbeta1-induced pathophysiologic disorders such as cancer metastasis and fibrosis. In this article, we will discuss the opposing effects of TGFbeta on tumor growth and metastasis, and address the signaling pathways regulated by PPARgamma for tumor progression and suppression.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.