ArticleJournal of the American Society of Nephrology : JASN2008
Macrophage stimulating protein may promote tubular regeneration after acute injury.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- High-volume hemofiltration does not protect human kidney endothelial and tubular epithelial cells from septic plasma-induced injury.Scientific reports · 2024Article
- Review
- RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.Haematologica · 2018Article
- Lipopolysaccharide-Induced Acute Kidney Injury Is Dependent on an IL-18 Receptor Signaling Pathway.International journal of molecular sciences · 2017Article
- Charge-based precipitation of extracellular vesicles.International journal of molecular medicine · 2016Article
- Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.Kidney international · 2015Article
- Cardiorenal Syndrome Type 1: Activation of Dual Apoptotic Pathways.Cardiorenal medicine · 2015Article
- Article
- Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.BMC immunology · 2014Article
- Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury.Stem cell research & therapy · 2014Article
- Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury.Stem cells and development · 2014Article
- CSF-1 signaling mediates recovery from acute kidney injury.The Journal of clinical investigation · 2012Article
- Intravenous renal cell transplantation for rats with acute and chronic renal failure.American journal of physiology. Renal physiology · 2012Article
- Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury.PloS one · 2012Article
- Proteomic signatures in plasma during early acute renal allograft rejection.Molecular & cellular proteomics : MCP · 2010Article
- Protective effect of resin adsorption on septic plasma-induced tubular injury.Critical care (London, England) · 2010Article
- CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice.The Journal of clinical investigation · 2009Article
- Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.Journal of the American Society of Nephrology : JASN · 2009Article
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after transplantation. In addition, MSP and its receptor, RON, were markedly upregulated in the regenerative phase after glycerol-induced tubular injury in mice. In vitro, MSP stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating Fas, mitochondrial proteins, Akt, and extracellular signal-regulated kinase. MSP also enhanced migration, scattering, branching morphogenesis, tubulogenesis, and mesenchymal de-differentiation of surviving tubular cells. In addition, MSP induced an embryonic phenotype characterized by Pax-2 expression. In conclusion, MSP is upregulated during the regeneration of injured tubular cells, and it exerts multiple biologic effects that may aid recovery from acute kidney injury.
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