ArticleThe American journal of clinical nutrition2008
Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction.
Article in The American journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies.Nutrients · 2024Pooled it
- Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.PLoS genetics · 2011Pooled it
- Trial
- Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults.Prostaglandins, leukotrienes, and essential fatty acids · 2014Trial
- Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited.PloS one · 2014Trial
- Multiomics reveals fatty acid metabolism and immune remodeling in retinal artery occlusion.iScience · 2026Article
- Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Review
- Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products.Archives of biochemistry and biophysics · 2023Article
- Comparison of dimension reduction methods on fatty acids food source study.Scientific reports · 2021Article
- Fatty acids and cardiometabolic health: a review of studies in Chinese populations.European journal of clinical nutrition · 2021Review
- The influence of nutritional state on the fatty acid composition of circulating lipid fractions: implications for their use as biomarkers of dietary fat intake.Upsala journal of medical sciences · 2021Article
- The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders.Biomolecules · 2020Review
- Review
- Article
- Article
- Validation of an equation predicting highly unsaturated fatty acid (HUFA) compositions of human blood fractions from dietary intakes of both HUFAs and their precursors.Prostaglandins, leukotrienes, and essential fatty acids · 2018Article
- Joint effects of fatty acid desaturase 1 polymorphisms and dietary polyunsaturated fatty acid intake on circulating fatty acid proportions.The American journal of clinical nutrition · 2018Article
- Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women's Health Initiative Memory Study (WHIMS).Prostaglandins, leukotrienes, and essential fatty acids · 2017Article
- Dietary intake of α-linolenic acid and risk of age-related macular degeneration.The American journal of clinical nutrition · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations.
objectiveWe aimed to investigate the effect of long-chain n-3 fatty acids in blood on the risk of nonfatal MI.
designBaseline blood samples were collected from 32 826 participants of the Nurses' Health Study in 1989-1990, among whom 146 incident cases of nonfatal MI were ascertained during 6 y of follow-up and matched with 288 controls.
resultsAfter multivariate adjustment, the relative risks (95% CI) comparing the highest with the lowest quartiles in plasma were 0.23 (0.09, 0.55; P for trend = 0.001) for eicosapentaenoic acid (EPA), 0.40 (0.20, 0.82; P for trend = 0.004) for docosapentaenoic acid (DPA), and 0.46 (0.18, 1.16; P for trend = 0.07) for docosahexaenoic acid (DHA). The associations for these fatty acids in erythrocytes were generally weaker and nonsignificant. In contrast to EPA and DHA, blood concentrations of DPA were not correlated with dietary consumption of n-3 fatty acids. Higher plasma concentrations of EPA, DPA, and DHA were associated with higher plasma concentrations of HDL cholesterol and lower concentrations of triacylglycerol and inflammatory markers.
conclusionsHigher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatal MI among women. These findings may partly reflect dietary consumption but, particularly for DPA, may indicate important risk differences based on metabolism of long-chain n-3 fatty acids.
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