ArticlePlant physiology2008
Manganese efficiency in barley: identification and characterization of the metal ion transporter HvIRT1.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68 citing papers in PubMed, 212 citations in OpenAlex.
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- Identification of Zinc Efficiency-Associated Loci (International journal of molecular sciences · 2022Article
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- Transcriptional regulation of metal metabolism- and nutrient absorption-related genes in Eucalyptus grandis by arbuscular mycorrhizal fungi at different zinc concentrations.BMC plant biology · 2022Article
- SgNramp1, a plasma membrane-localized transporter, involves in manganese uptake inFrontiers in plant science · 2022Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2021Article
- Cadmium uptake via apoplastic bypass flow in Oryza sativa.Journal of plant research · 2021Article
- Cd tolerance and accumulation in barley: screening of 36 North African cultivars on Cd-contaminated soil.Environmental science and pollution research international · 2021Article
- Transcriptional Regulation of Genes Involved in Zinc Uptake, Sequestration and Redistribution Following Foliar Zinc Application toPlants (Basel, Switzerland) · 2021Article
- Genome-Wide Identification of Wheat ZIP Gene Family and Functional Characterization of theFrontiers in plant science · 2021Article
- Importance of the Rhizosphere Microbiota in Iron Biofortification of Plants.Frontiers in plant science · 2021Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese (Mn) deficiency is an important plant nutritional disorder in many parts of the world. Barley (Hordeum vulgare) genotypes differ considerably in their ability to grow in soils with low Mn(2+) availability. Differential genotypic Mn efficiency can be attributed to differences in Mn(2+) uptake kinetics in the low nanomolar concentration range. However, the molecular basis for these differences has not yet been clarified. We present here the identification and characterization of the first barley gene encoding a plasma membrane-localized metal transport protein able to transport Mn(2+). The gene is designated HvIRT1 (for IRON-REGULATED TRANSPORTER1) because it belongs to the ZIP gene family and has a high similarity to rice (Oryza sativa) OsIRT1. A novel yeast uptake assay based on inductively coupled plasma-mass spectrometry analysis of 31 different metal and metalloid ions showed that the HvIRT1 protein, in addition to Mn(2+), also transported Fe(2+)/Fe(3+), Zn(2+), and Cd(2+). Both Mn and iron deficiency induced an up-regulation of HvIRT1 in two barley genotypes differing in Mn efficiency, but the expression levels in all cases were highest (up to 40%) in the Mn-efficient genotype. The higher expression of HvIRT1 correlated with an increased Mn(2+) uptake rate. We conclude that HvIRT1 is an important component controlling Mn(2+) uptake in barley roots and contributes to genotypic differences in Mn(2+) uptake kinetics.
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