ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Complete Loss of Myelin protein zero (MPZ) in a patient with a late onset Charcot-Marie-Tooth (CMT).Metabolic brain disease · 2023Article
- A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communication.PLoS genetics · 2022Article
- New Species Can Broaden Myelin Research: Suitability of Little Skate,Life (Basel, Switzerland) · 2021Article
- How Does Protein Zero Assemble Compact Myelin?Cells · 2020Article
- Influence of Mechanical Stimuli on Schwann Cell Biology.Frontiers in cellular neuroscience · 2017Review
- Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling.The Journal of cell biology · 2016Article
- Axon degeneration: Linking axonal bioenergetics to myelin.The Journal of cell biology · 2016Article
- Article
- PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking.The American journal of pathology · 2012Article
- Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease.Journal of anatomy · 2011Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Axons in the PNS and CNS are ensheathed by multiple layers of tightly compacted myelin membranes. A series of cytoplasmic channels connect outer and inner margins of PNS, but not CNS, myelin internodes. Membranes of these Schmidt-Lantermann (S-L) incisures contain the myelin-associated glycoprotein (MAG) but not P(0) or proteolipid protein (PLP), the structural proteins of compact PNS (P(0)) and CNS (PLP) myelin. We show here that incisures are present in MAG-null and absent from P(0)-null PNS internodes. To test the possibility that P(0) regulates incisure formation, we replaced PLP with P(0) in CNS myelin. S-L incisures formed in P(0)-CNS myelin internodes. Furthermore, axoplasm ensheathed by 65% of the CNS incisures examined by electron microscopy had focal accumulations of organelles, indicating that these CNS incisures disrupt axonal transport. These data support the hypotheses that P(0) protein is required for and can induce S-L incisures and that P(0)-induced CNS incisures can be detrimental to axonal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.