ArticleNeuron2008
Extent of voltage sensor movement during gating of shaker K+ channels.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Article
- The 70-year search for the voltage-sensing mechanism of ion channels.The Journal of physiology · 2022Article
- Voltage-dependent gating in K channels: experimental results and quantitative models.Pflugers Archiv : European journal of physiology · 2020Review
- Article
- Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET.Biophysical journal · 2018Article
- Voltage and pH sensing by the voltage-gated proton channel, HJournal of the Royal Society, Interface · 2018Review
- Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Probing Polytopic Membrane Protein-Substrate Interactions by Luminescence Resonance Energy Transfer.Journal of the American Chemical Society · 2016Article
- The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter.The Journal of biological chemistry · 2016Article
- Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1.Progress in biophysics and molecular biology · 2016Article
- Structure of potassium channels.Cellular and molecular life sciences : CMLS · 2015Review
- Probing α-3(10) transitions in a voltage-sensing S4 helix.Biophysical journal · 2014Article
- Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.Nature structural & molecular biology · 2014Article
- Functional analysis and regulation of purified connexin hemichannels.Frontiers in physiology · 2014Review
- Tethered spectroscopic probes estimate dynamic distances with subnanometer resolution in voltage-dependent potassium channels.Biophysical journal · 2013Article
- S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.Biophysical journal · 2013Article
- Association/dissociation of the nucleotide-binding domains of the ATP-binding cassette protein MsbA measured during continuous hydrolysis.The Journal of biological chemistry · 2013Article
- Energetic role of the paddle motif in voltage gating of Shaker K(+) channels.Nature structural & molecular biology · 2013Article
- Voltage sensor ring in a native structure of a membrane-embedded potassium channel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Voltage-driven activation of Kv channels results from conformational changes of four voltage sensor domains (VSDs) that surround the K(+) selective pore domain. How the VSD helices rearrange during gating is an area of active research. Luminescence resonance energy transfer (LRET) is a powerful spectroscopic ruler uniquely suitable for addressing the conformational trajectory of these helices. Using a geometric analysis of numerous LRET measurements, we were able to estimate LRET probe positions relative to existing structural models. The experimental movement of helix S4 does not support a large 15-20 A transmembrane "paddle-type" movement or a near-zero A vertical "transporter-type" model. Rather, our measurements demonstrate a moderate S4 displacement of 10 +/- 5 A, with a vertical component of 5 +/- 2 A. The S3 segment moves 2 +/- 1 A in the opposite direction and is therefore not moving as an S3-S4 rigid body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.