ArticleVirology journal2008
Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections.Cell host & microbe · 2017Article
- Hepatitis C virus infection: Are there still specific problems with genotype 3?World journal of gastroenterology · 2015Review
- Article
- Article
- Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity.Journal of virology · 2012Article
- The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals.The Journal of general virology · 2011Review
- Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics.Genome medicine · 2011Article
- Hepatitis C virus quasispecies in chronically infected children subjected to interferon-ribavirin therapy.Archives of virology · 2010Article
- Potential treatment options and future research to increase hepatitis C virus treatment response rate.Hepatic medicine : evidence and research · 2010Article
- Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.The Journal of infectious diseases · 2010Article
- The quasispecies nature and biological implications of the hepatitis C virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Predicting response to hepatitis C therapy.The Journal of clinical investigation · 2009Article
- Separation of Hepatitis C genotype 4a into IgG-depleted and IgG-enriched fractions reveals a unique quasispecies profile.Virology journal · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-treatment HCV quasispecies complexity and diversity may predict response to interferon based anti-viral therapy. The objective of this study was to retrospectively (1) examine temporal changes in quasispecies prior to the start of therapy and (2) investigate extensively quasispecies evolution in a group of 10 chronically infected patients with genotype 3a, treated with pegylated alpha2a-Interferon and ribavirin. The degree of sequence heterogeneity within the hypervariable region 1 was assessed by analyzing 20-30 individual clones in serial serum samples. Genetic parameters, including amino acid Shannon entropy, Hamming distance and genetic distance were calculated for each sample. Treatment outcome was divided into (1) sustained virological responders (SVR) and (2) treatment failure (TF). Our results indicate, (1) quasispecies complexity and diversity are lower in the SVR group, (2) quasispecies vary temporally and (3) genetic heterogeneity at baseline can be use to predict treatment outcome. We discuss the results from the perspective of replicative homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.