ReviewImmunological reviews2008
How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets.
Review in Immunological reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01780857 (The Immune Signature of Palmoplantar Pustulosis), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Immune Signature of Palmoplantar Pustulosis
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?Arthritis research & therapy · 2016Pooled it
- Pooled it
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- A Multifaceted Interplay Among Hemophagocytosis, Interleukin-18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Elevated Histamine Receptor 2 and Toll-Like Receptor 7 Expression in Rheumatoid Arthritis: Insights Into Inflammatory Mechanisms and Potential Therapeutic Strategies.International journal of rheumatic diseases · 2026Article
- Dietary supplementation of β-conglycinin, with or without sodium butyrate on the growth, immune response and intestinal health of hybrid grouper.Scientific reports · 2021Article
- BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R.Bioinformatics (Oxford, England) · 2021Article
- Effective litmus gene test for monitoring the quality of blood samples: Application to Alzheimer's disease diagnostics.Scientific reports · 2017Article
- Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home.Clinical and experimental immunology · 2017Article
- MCMDA: Matrix completion for MiRNA-disease association prediction.Oncotarget · 2017Article
- Monogenic Autoinflammatory Diseases with Mendelian Inheritance: Genes, Mutations, and Genotype/Phenotype Correlations.Frontiers in immunology · 2017Review
- A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research.F1000Research · 2016Article
- A compendium of monocyte transcriptome datasets to foster biomedical knowledge discovery.F1000Research · 2016Article
- Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus.The Journal of allergy and clinical immunology · 2015Article
- Decade in review-paediatric rheumatology: A field on the move.Nature reviews. Rheumatology · 2015Article
- Update on genetics and pathogenesis of autoinflammatory diseases: the last 2 years.Seminars in immunopathology · 2015Review
- Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations.Journal of autoimmunity · 2015Article
- A vision and a prescription for big data-enabled medicine.Nature immunology · 2015Article
- Democratizing systems immunology with modular transcriptional repertoire analyses.Nature reviews. Immunology · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
summaryOur studies in children with rheumatic diseases have led to the identification of two of the oldest cytokines, type I interferon (IFN) and interleukin 1 (IL-1), as important pathogenic players in systemic lupus erythematosus (SLE) and systemic onset juvenile arthritis (SoJIA), respectively. These findings were obtained by studying the transcriptional profiles of patient blood cells and by assessing the biological and transcriptional effect(s) of active patient sera on healthy blood cells. We also identified a signature that can be used to promptly diagnose SoJIA from other febrile conditions. Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.