ArticleJournal of the American Chemical Society2008
Selective disruption of early/recycling endosomes: release of disulfide-linked cargo mediated by a N-alkyl-3beta-cholesterylamine-capped peptide.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.Nature communications · 2022Article
- Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery.iScience · 2020Article
- Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide.ACS omega · 2019Article
- Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo.Angewandte Chemie (International ed. in English) · 2015Article
- Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells.Chemical communications (Cambridge, England) · 2015Article
- Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.Journal of the American Chemical Society · 2013Article
- Bivalent ligands targeting multiple pathological factors involved in Alzheimer's disease.ACS medicinal chemistry letters · 2012Article
- Synthetic cell surface receptors for delivery of therapeutics and probes.Advanced drug delivery reviews · 2012Review
- Toward a general approach for RNA-templated hierarchical assembly of split-proteins.Journal of the American Chemical Society · 2010Article
- Subcellular targeting strategies for drug design and delivery.Nature reviews. Drug discovery · 2010Review
- Fluorinated lipid constructs permit facile passage of molecular cargo into living cells.Journal of the American Chemical Society · 2009Article
- Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.Journal of medicinal chemistry · 2009Article
- Practical synthesis of 3beta-amino-5-cholestene and related 3beta-halides involving i-steroid and retro-i-steroid rearrangements.Organic letters · 2009Article
- Lipid modification of proteins through sortase-catalyzed transpeptidation.Journal of the American Chemical Society · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The use of endocytic uptake pathways to deliver poorly permeable molecules into mammalian cells is often plagued by entrapment and degradation of material in late endosomes and lysosomes. As a strategy to prevent the exposure of cargo to these highly hydrolytic membrane-sealed compartments, we synthesized derivatives of the membrane anchor N-alkyl-3beta-cholesterylamine that selectively target linked compounds to less hydrolytic early/recycling endosomes. By targeting a pH-dependent membrane-lytic dodecapeptide and a disulfide-linked fluorophore to these compartments in Chinese hamster ovary cells or Jurkat lymphocytes, membranes of early/recycling endosomes were selectively disrupted, resulting in cleavage of the disulfide and escape of the fluorophore into the cytosol and nucleus with low toxicity. The ability of appropriately designed N-alkyl-3beta-cholesterylamines to deliver cargo into and release disulfide-linked cargo from relatively nonhydrolytic early/recycling endosomes may be useful for the delivery of a variety of sensitive molecules into living mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.