ArticleCancer immunity2008
Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.
Article in Cancer immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target.Frontiers in oncology · 2024Review
- Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity.Pharmaceutics · 2023Review
- Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells.Frontiers in immunology · 2022Review
- Overcoming the UCB HSCs -Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways.Cancer cell international · 2021Article
- The Role of the NKG2D in Vitiligo.Frontiers in immunology · 2021Review
- Role of Heat Shock Proteins in Immune Modulation in Malaria.Advances in experimental medicine and biology · 2021Article
- The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease.Frontiers in immunology · 2018Review
- CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2.Immunity & ageing : I & A · 2018Article
- Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.Pathology oncology research : POR · 2017Article
- Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.Current drug targets · 2017Review
- Recombinant heat shock protein 70 functional peptide and alpha-fetoprotein epitope peptide vaccine elicits specific anti-tumor immunity.Oncotarget · 2016Article
- MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner.Frontiers in immunology · 2016Article
- Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones.International review of neurobiology · 2016Review
- Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity.Oncotarget · 2014Article
- NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses.Frontiers in immunology · 2012Article
- Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.The open inflammation journal · 2011Article
- Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation.Cell stress & chaperones · 2011Article
- Modulatory role of calreticulin as chaperokine for dendritic cell-based immunotherapy.Clinical and experimental immunology · 2011Article
- Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model.Cell stress & chaperones · 2010Article
- Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells.Anti-cancer agents in medicinal chemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported that heat shock protein 70 (HSP70) vaccination induced natural killer (NK) cell activity in patients with chronic myelogenous leukemia (CML). In this study, HSP70 of both autologous and allogeneic origin was found to stimulate IFN-gamma production from peripheral blood mononuclear cells of CML patients, as well as of normal subjects. Further investigations demonstrated that the activity of HSP70 was dependent on both NK cells and dendritic cells (DCs). HSP70 did not induce significant IFN-gamma production from either NK cells or DCs alone. Mechanistically, we found that HSP70-mediated DC-NK cell crosstalk required cell-cell contact, which could be inhibited completely by neutralizing antibody against NK activating receptor NKG2D. The significance of NKG2D was further corroborated by the finding that HSP70 induced the expression of an NKG2D ligand, the MHC class I chain-related protein A (MICA), on DCs; HSP70-augmented IFN-gamma release was abrogated by antibody against MICA. Thus extracellular HSP70, released during either stress or inflammatory cell death, may serve as a critical link between NK and DCs in mounting immune responses against infections, cancers and self-antigens.
Indexed as
Identifiers
18613644PMC2935777W2102303186What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.