Evidence map›Paper›PMID 18613267›Full record

ReviewInternational journal of geriatric psychiatry2009

Bringing the bedside to the bench, and then to the community: a prospectus for intervention research in late-life anxiety disorders.

Eric J Lenze, Julie Loebach Wetherell

Abstract readReview
In one paragraph

Review in International journal of geriatric psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 57 citations in OpenAlex.

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  5. Emotion reactivity and regulation in late-life generalized anxiety disorder: functional connectivity at baseline and post-treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015
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  7. Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder.The British journal of psychiatry : the journal of mental science · 2011
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  8. Article
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  11. White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Article
  12. Article
  13. Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eric J LenzeThe Department of Psychiatry, Washington University School of Medicine, Washington, USA. lenzee@wustl.edu
Julie Loebach Wetherell
University of Washington · USVA San Diego Healthcare System · US

Funding

Pharmacotherapy of Latelife Generalized Anxiety DisorderR01MH070547 · NIMH · WASHINGTON UNIVERSITY · PI LENZE, ERIC J · 2005 to 2009
$1.3M
New Intervention for Geriatric Anxiety in Primary CareK23MH067643 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WETHERELL, JULIE L · 2003 to 2007
$723k
CBT Augmentation of SSRI Treatment for Geriatric GADR34MH080151 · NIMH · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI WETHERELL, JULIE L · 2007 to 2009
$552k
NIMH NIH HHS K23 MH067643NIMH NIH HHS R01 MH070547NIMH NIH HHS R34 MH080151
6 · The paper itself

Abstract

backgroundAnxiety disorders are highly prevalent in elderly persons, and they are associated with functional impairment, poorer quality of life, and adverse long-term consequences such as cognitive decline. Intervention research in late-life anxiety disorders (LLAD) lags behind where it ought to be. Research in cognitive neuroscience, aging, and stress intersects in LLAD and provides the opportunity to develop innovative interventions to prevent chronic anxiety and its consequences in this age group.

methodsThis paper evaluates gaps in the evidence base for treatment of LLAD and synthesizes recent research in cognitive neuroscience, basic behavioral science, stress, and aging.

resultsWe examine three intervention issues in LLAD: (1) prevention; (2) acute treatment; and (3) pre-empting adverse consequences. We propose combining randomized controlled trials (RCTs) with mechanistic biobehavioral methodologies as an optimal approach for developing novel, optimized, and personalized treatments. Additionally, we examine three barriers in the field of LLAD research: (1) How do we measure anxiety?; (2) How do we raise awareness?; (3) How will we ensure our research is applicable to underserved populations (particularly minority groups)?

conclusionsThis prospectus outlines approaches for intervention research that can reduce the morbidity of LLAD.

Indexed as

Evidence-Based MedicineAgedAgingAnxiety DisordersBehavioral ResearchCognitive ScienceHumansRandomized Controlled Trials as TopicResearchStress, Psychological

Identifiers

PMID18613267
PMCPMC3635100
OpenAlexW2123321838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.