ArticleGenetic epidemiology2008
CANDID: a flexible method for prioritizing candidate genes for complex human traits.
Article in Genetic epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- DeepGenePrior: A deep learning model for prioritizing genes affected by copy number variants.PLoS computational biology · 2023Article
- Osteogenesis imperfecta in a male holstein calf associated with a possible oligogenic origin.The veterinary quarterly · 2020Article
- Hypothesis: protein and RNA attributes are continuously optimized over time.BMC genomics · 2019Article
- Genome-wide prediction and prioritization of human aging genes by data fusion: a machine learning approach.BMC genomics · 2019Article
- Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module.Scientific reports · 2018Article
- Gene prioritization using Bayesian matrix factorization with genomic and phenotypic side information.Bioinformatics (Oxford, England) · 2018Article
- Scuba: scalable kernel-based gene prioritization.BMC bioinformatics · 2018Article
- Comprehensive Analysis of Tissue-wide Gene Expression and Phenotype Data Reveals Tissues Affected in Rare Genetic Disorders.Cell systems · 2017Article
- Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis.BMC medical genomics · 2017Article
- Genomic and transcriptomic predictors of response levels to endurance exercise training.The Journal of physiology · 2017Review
- GenePANDA-a novel network-based gene prioritizing tool for complex diseases.Scientific reports · 2017Article
- Dintor: functional annotation of genomic and proteomic data.BMC genomics · 2015Article
- Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.JAMA neurology · 2015Article
- GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles.Bioinformatics (Oxford, England) · 2015Article
- A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.Human molecular genetics · 2015Article
- RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs.Nucleic acids research · 2015Article
- Article
- Exome sequencing greatly expedites the progressive research of Mendelian diseases.Frontiers of medicine · 2014Review
- Text mining in cancer gene and pathway prioritization.Cancer informatics · 2014Review
- Combining heterogenous data for prediction of disease related and pharmacogenes.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Genomewide studies and localized candidate gene approaches have become everyday study designs for identifying polymorphisms in genes that influence complex human traits. Yet, in general, the number of significant findings and the need to focus on smaller regions require a prioritization of genes for further study. Some candidate gene identification algorithms have been proposed in recent years to attempt to streamline this prioritization, but many suffer from limitations imposed by the source data or are difficult to use and understand. CANDID is a prioritization algorithm designed to produce impartial, accurate rankings of candidate genes that influence complex human traits. CANDID can use information from publications, protein domain descriptions, cross-species conservation measures, gene expression profiles and protein-protein interactions in its analysis. Additionally, users may supplement these data sources with results from linkage, association and other studies. CANDID was tested on well-known complex trait genes using data from the Online Mendelian Inheritance in Man database. Additionally, CANDID was evaluated in a modeled gene discovery environment, where it ranked genes whose trait associations were published after CANDID's databases were compiled. In all settings, CANDID exhibited high sensitivity and specificity, indicating an improvement upon previously published algorithms. Its accuracy and ease of use make CANDID a highly useful tool in study design and analysis for complex human traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.