ArticleDigestive diseases and sciences2009
Helicobacter pylori cagA status and peptic ulcer disease in Iran.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comparison ofJGH open : an open access journal of gastroenterology and hepatology · 2024Article
- The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency inBioMed research international · 2019Article
- Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori.BMC gastroenterology · 2014Article
- CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study.Medical journal of the Islamic Republic of Iran · 2014Article
- Low frequency of cagA-positive Helicobacter pylori strains isolated from Iranian patients with MALT lymphoma.Internal and emergency medicine · 2013Article
- Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran.Internal and emergency medicine · 2012Article
- Detection of helicobacter pylori in benign laryngeal lesions by polymerase chain reaction: a cross sectional study.Infectious agents and cancer · 2012Article
- Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran.Journal of clinical microbiology · 2011Article
- Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer.BMC microbiology · 2011Article
- Seroprevalence of anti-Hp and anti-cagA antibodies among healthy persons in Golestan province, northeast of Iran (2010).Caspian journal of internal medicine · 2011Article
- The significance of E266K polymorphism in the NOD1 gene on Helicobacter pylori infection: an effective force on pathogenesis?Clinical and experimental medicine · 2010Article
- Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population.Journal of gastroenterology and hepatology · 2010Article
- Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.Annals of clinical microbiology and antimicrobials · 2009Article
- The distribution of cagA and dupA genes in Helicobacter pylori strains in Kurdistan region, northern Iraq.Annals of Saudi medicineArticle
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6 authors.
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Abstract
Helicobacter pylori contributes to the development of peptic ulcers and atrophic gastritis. Furthermore, H. pylori strains carrying the cagA gene are more virulent than cagA -negative strains and are associated with the development of gastric adenocarcinoma. The cagA gene is a putative H. pylori virulence factor of unknown function. The aim of this study was to determine the prevalence of the cagA gene among H. pylori isolates and its relationship with peptic ulcer disease in 128 Iranian patients. A total of 107 (83.6%) samples were positive, including 40 (95%) of the 42 patients with duodenal ulcer, 43 (86%) of the 50 patients with gastric ulcer, and 24 (66.6%) of the 36 patients with gastritis. cagA was present in 32 (80%) of 40 strains from duodenal ulcer patients, 33 (77%) of 43 strains from gastric ulcer patients, and 11 (46%) of 24 from gastritis patients. We also attempted to investigate the subtypes of 3' region of cagA gene in H. pylori strains isolated from Iranian patients and their relation to H. pylori-associated gastroduodenal diseases. The PCR product of cagA positive strains obtained with primer set CAG1/CAG2 differed in size, varying from 642 to 651 bp (subtype A) in 33 isolates to 756 bp (subtype B/D) in 13 isolates. This does not support the view that subtypes of the 3' region of cagA gene in H. pylori isolated from Iran correlate with the clinical outcomes of H. pylori, but colonization with cagA positive strains was significantly higher among duodenal ulcer than gastritis patients in Iran.
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