ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2008
Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.Scientific reports · 2016Pooled it
- Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis.Clinical and experimental immunology · 2010Pooled it
- Tuberculosis susceptibility and protection in children.The Lancet. Infectious diseases · 2019Review
- Genetic association of MBL-2 gene polymorphisms with Filarial chyluria.Bioinformation · 2019Article
- Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.Infection and drug resistance · 2019Article
- Genetic polymorphisms ofArchives of medical science : AMS · 2018Review
- Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies.Infection and drug resistance · 2018Article
- Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility.Frontiers in medicine · 2018Review
- Mannose-Binding Lectin (Genomics data · 2017Article
- C-type lectin receptors in tuberculosis: what we know.Medical microbiology and immunology · 2016Review
- No Strong Relationship Between Components of the Lectin Pathway of Complement and Susceptibility to Pulmonary Tuberculosis.Inflammation · 2015Article
- Extra-pulmonary tuberculosis: a biomarker analysis.Infection · 2014Article
- Mannose-binding lectin and susceptibility to schistosomiasis.The Journal of infectious diseases · 2013Article
- Tag SNP polymorphism of CCL2 and its role in clinical tuberculosis in Han Chinese pediatric population.PloS one · 2011Article
- Infections of people with complement deficiencies and patients who have undergone splenectomy.Clinical microbiology reviews · 2010Review
- Serum mannan-binding lectin in patients with pulmonary tuberculosis: Its lack of a relationship to the disease and response to treatment.Medical journal of the Islamic Republic of IranArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mannose-binding lectin (MBL) plays an important role in innate immunity mediating phagocytosis and activating the MBL complement pathway. Few studies, conducted in adult populations, have shown that genetically determined low MBL levels may confer partial protection against tuberculosis (TB). In this study we aimed to investigate the relationships between the susceptibility to TB and two low producing MBL2 gene polymorphisms (codons 54 and 57) and MBL levels in children. Forty-four TB children (27 pulmonary TB, 17 extrapulmonary TB) and 99 age-matched healthy control children were included in the study. The mean age in the study group was 7.02 +/- 4.5 years. Genotyping of the MBL2 gene for codon 54 and 57 polymorphisms was carried out, and MBL levels in serum were also detected in all subjects from both groups. None of the subjects from either group showed codon 57 polymorphisms. The frequency of the AB genotype which produces low level MBL is significantly lower in the patients (9.1%) compared to control subjects (27.3%) (p < 0.011). The difference was especially significant between the extrapulmonary group and healthy controls (p < 0.006). The BB genotype was observed in only one child from the healthy controls and no children from the patient group. The median MBL plasma concentration was also significantly lower in the control group than that found in the study group (p = 0.036). These results indicate that low levels of MBL and AB genotype may be involved in the protection against tuberculosis, especially extrapulmonary tuberculosis in children.
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