ReviewJournal of mathematical biology2009
Models for actin polymerization motors.
Review in Journal of mathematical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- From solution to surface to filament: actin flux into branched networks.Biophysical reviews · 2018Review
- Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Using active colloids as machines to weave and braid on the micrometer scale.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.PLoS biology · 2014Article
- Measuring forces at the leading edge: a force assay for cell motility.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton.The Journal of cell biology · 2011Review
- Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective.Journal of cell science · 2011Review
- Molecular mechanism of Ena/VASP-mediated actin-filament elongation.The EMBO journal · 2011Article
- Dicing with dogma: de-branching the lamellipodium.Trends in cell biology · 2010Article
- Force generation of curved actin gels characterized by combined AFM-epifluorescence measurements.Biophysical journal · 2010Article
- Electron tomography reveals unbranched networks of actin filaments in lamellipodia.Nature cell biology · 2010Article
- Two competing orientation patterns explain experimentally observed anomalies in growing actin networks.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Actin polymerization drives cell membrane protrusions and the propulsion of intracellular pathogens. The molecular mechanisms driving actin polymerization are not yet fully understood. Various mathematical models have been proposed to explain how cells convert chemical energy released upon actin polymerization into a pushing force on a surface. These models have attempted to explain puzzling properties of actin-based motility, including persistent attachment of the network to the membrane during propulsion and the interesting trajectories of propelled particles. These models fall generally into two classes: those requiring filament (+)-ends to fluctuate freely from the membrane to add subunits, and those where filaments elongate with their (+)-ends persistently associated with surface through filament end-tracking proteins ("actoclampin" models). This review compares and contrasts the key predictions of these two classes of models with regard to force-velocity profiles, and evaluates them with respect to experiments with biomimetic particles, and the experimental evidence on the role of end-tracking proteins such as formins and nucleation-promoting factors in actin-based motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.