ArticlePloS one2008
Hedonic taste in Drosophila revealed by olfactory receptors expressed in taste neurons.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Whole Exome Sequencing Study Identifies Novel Rare Risk Variants for Habitual Coffee Consumption Involved in Olfactory Receptor and Hyperphagia.Nutrients · 2022Article
- Review
- Mammalian Taste Cells Express Functional Olfactory Receptors.Chemical senses · 2019Article
- Two Olfactory Pathways to Detect Aldehydes on Locust Mouthpart.International journal of biological sciences · 2017Article
- Gustatory processing and taste memory in Drosophila.Journal of neurogenetics · 2016Review
- Dual mechanism for bitter avoidance in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Drosophila Bitter Taste(s).Frontiers in integrative neuroscience · 2015Review
- A comparative analysis of neural taste processing in animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Dynamic characterization of Drosophila antennal olfactory neurons indicates multiple opponent signaling pathways in odor discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Review
- Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death.Neural development · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taste and olfaction are each tuned to a unique set of chemicals in the outside world, and their corresponding sensory spaces are mapped in different areas in the brain. This dichotomy matches categories of receptors detecting molecules either in the gaseous or in the liquid phase in terrestrial animals. However, in Drosophila olfactory and gustatory neurons express receptors which belong to the same family of 7-transmembrane domain proteins. Striking overlaps exist in their sequence structure and in their expression pattern, suggesting that there might be some functional commonalities between them. In this work, we tested the assumption that Drosophila olfactory receptor proteins are compatible with taste neurons by ectopically expressing an olfactory receptor (OR22a and OR83b) for which ligands are known. Using electrophysiological recordings, we show that the transformed taste neurons are excited by odor ligands as by their cognate tastants. The wiring of these neurons to the brain seems unchanged and no additional connections to the antennal lobe were detected. The odor ligands detected by the olfactory receptor acquire a new hedonic value, inducing appetitive or aversive behaviors depending on the categories of taste neurons in which they are expressed i.e. sugar- or bitter-sensing cells expressing either Gr5a or Gr66a receptors. Taste neurons expressing ectopic olfactory receptors can sense odors at close range either in the aerial phase or by contact, in a lipophilic phase. The responses of the transformed taste neurons to the odorant are similar to those obtained with tastants. The hedonic value attributed to tastants is directly linked to the taste neurons in which their receptors are expressed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.