SynthesisPloS one2008
Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques.
Synthesis in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- GSMA: an approach to identify robust global and test Gene Signatures using Meta-Analysis.Bioinformatics (Oxford, England) · 2020Pooled it
- Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections.PLoS neglected tropical diseases · 2016Pooled it
- Rethinking Meta-Analysis: Applications for Air Pollution Data and Beyond.Risk analysis : an official publication of the Society for Risk Analysis · 2015Pooled it
- A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections.BMC systems biology · 2011Pooled it
- Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources.BMC genomics · 2011Pooled it
- Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma.Bioscience reports · 2021Article
- Safranal Alleviated OVA-Induced Asthma Model and Inhibits Mast Cell Activation.Frontiers in immunology · 2021Article
- Toxicogenomic analysis of publicly available transcriptomic data can predict food, drugs, and chemical-induced asthma.Pharmacogenomics and personalized medicine · 2019Article
- Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion.International urology and nephrology · 2018Article
- Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge.Frontiers in immunology · 2017Article
- Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases.Frontiers in genetics · 2016Article
- Single-nucleotide polymorphisms reveal patterns of allele sharing across the species boundary between rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques.American journal of primatology · 2013Article
- Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.Infection and immunity · 2012Article
- Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.Molecular systems biology · 2012Article
- Comprehensive literature review and statistical considerations for microarray meta-analysis.Nucleic acids research · 2012Review
- MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets.PloS one · 2011Article
- Article
- Genome wide transcriptome profiling of a murine acute melioidosis model reveals new insights into how Burkholderia pseudomallei overcomes host innate immunity.BMC genomics · 2010Article
- Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A.BMC medical genomics · 2010Article
- Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia.Respiratory research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify gene expression responses common to multiple pulmonary diseases we collected microarray data for acute lung inflammation models from 12 studies and used these in a meta-analysis. The data used include exposures to air pollutants; bacterial, viral, and parasitic infections; and allergic asthma models. Hierarchical clustering revealed a cluster of 383 up-regulated genes with a common response. This cluster contained five subsets, each characterized by more specific functions such as inflammatory response, interferon-induced genes, immune signaling, or cell proliferation. Of these subsets, the inflammatory response was common to all models, interferon-induced responses were more pronounced in bacterial and viral models, and a cell division response was more prominent in parasitic and allergic models. A common cluster containing 157 moderately down-regulated genes was associated with the effects of tissue damage. Responses to influenza in macaques were weaker than in mice, reflecting differences in the degree of lung inflammation and/or virus replication. The existence of a common cluster shows that in vivo lung inflammation in response to various pathogens or exposures proceeds through shared molecular mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.