ArticleHuman heredity2008
LPA and PLG sequence variation and kringle IV-2 copy number in two populations.
Article in Human heredity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.Journal of lipid research · 2017Pooled it
- Role of Lipoprotein(a) in Atherosclerotic Cardiovascular Disease in South Asian Individuals.Journal of the American Heart Association · 2025Review
- A Multiplexed Quantitative Proteomics Approach to the Human Plasma Protein Signature.Biomedicines · 2024Article
- Lipoprotein(a): a Case for Universal Screening in Youth.Current atherosclerosis reports · 2023Review
- Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene.Atherosclerosis · 2022Review
- Lipoprotein(a) in atherosclerosis: from pathophysiology to clinical relevance and treatment options.Annals of medicine · 2020 · on this mapReview
- A comprehensive map of single-base polymorphisms in the hypervariableJournal of lipid research · 2019Article
- Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis.G3 (Bethesda, Md.) · 2016Article
- Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.Human molecular genetics · 2015Article
- Sequence variation within the KIV-2 copy number polymorphism of the human LPA gene in African, Asian, and European populations.PloS one · 2015Article
- Lipoprotein (a): structure, pathophysiology and clinical implications.Arquivos brasileiros de cardiologia · 2014 · on this mapReview
- Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey.PloS one · 2011Article
- Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.Stroke · 2011Article
- Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.Journal of lipid research · 2009 · on this mapArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsLp(a) levels have long been recognized as a potential risk factor for coronary heart disease that is almost completely under genetic control. Much of the genetics impacting Lp(a) levels has been attributed to the highly polymorphic LPA kringle IV-2 copy number variant, and most of the variance in Lp(a) levels in populations of European-descent is inversely correlated with kringle IV copy number. However, less of the variance is explained in African-descent populations for the same structural variation. African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations.
methodsTo identify potential cis-acting factors, we re-sequenced the gene LPA for single nucleotide polymorphism (SNP) discovery in 23 European-Americans and 24 African-Americans. We also re- sequenced the neighboring gene plasminogen (PLG) and genotyped the kringle IV copy number variant in the same reference samples.
resultsThese data are the most comprehensive description of sequence variation in LPA and its relationship with the kringle IV copy number variant. With these data, we demonstrate that only a fraction of LPA sequence diversity has been previously documented. Also, we identify several high frequency SNPs present in the African-American sample but absent in the European-American sample. Finally, we show that SNPs within PLG are not in linkage disequilibrium with SNPs in LPA, and we show that kringle IV copy number variation is not in linkage disequilibrium with either LPA or PLG SNPs.
conclusionsTogether, these data suggest that LPA SNPs could independently contribute to Lp(a) levels in the general population.
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