ArticleStructure (London, England : 1993)2008
Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
Article in Structure (London, England : 1993), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions.BMC systems biology · 2018Article
- Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia.Odontology · 2017Article
- Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs.Methods in molecular biology (Clifton, N.J.) · 2015Article
- ValidatorDB: database of up-to-date validation results for ligands and non-standard residues from the Protein Data Bank.Nucleic acids research · 2015Article
- Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?British journal of pharmacology · 2012Review
- RACK1, A multifaceted scaffolding protein: Structure and function.Cell communication and signaling : CCS · 2011Article
- Retromer terminates the generation of cAMP by internalized PTH receptors.Nature chemical biology · 2011Article
- Structure and function of WD40 domain proteins.Protein & cell · 2011Review
- Article
- Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Cellular and molecular life sciences : CMLS · 2011Review
- Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission.Nature structural & molecular biology · 2011Article
- Designing coarse grained-and atom based-potentials for protein-protein docking.BMC structural biology · 2010Article
- NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance.Methods in molecular biology (Clifton, N.J.) · 2010Article
- Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain.Journal of molecular biology · 2009Article
Corrections and comments
- Retraction · 2008-07-09Error in Results and/or Conclusions · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A critical role of the Gbetagamma dimer in heterotrimeric G-protein signaling is to facilitate the engagement and activation of the Galpha subunit by cell-surface G-protein-coupled receptors. However, high-resolution structural information of the connectivity between receptor and the Gbetagamma dimer has not previously been available. Here, we describe the structural determinants of Gbeta1gamma2 in complex with a C-terminal region of the parathyroid hormone receptor-1 (PTH1R) as obtained by X-ray crystallography. The structure reveals that several critical residues within PTH1R contact only Gbeta residues located within the outer edge of WD1- and WD7-repeat segments of the Gbeta toroid structure. These regions encompass a predicted membrane-facing region of Gbeta thought to be oriented in a fashion that is accessible to the membrane-spanning receptor. Mutation of key receptor contact residues on Gbeta1 leads to a selective loss of function in receptor/heterotrimer coupling while preserving Gbeta1gamma2 activation of the effector phospholipase-C beta.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.