ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2008
Multimorbidity and risk among patients with established cardiovascular disease: a cohort study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quality-improvement strategies for the management of hypertension in chronic kidney disease in primary care: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010Pooled it
- Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial.Journal of the American Heart Association · 2017Trial
- Audit-based education lowers systolic blood pressure in chronic kidney disease: the Quality Improvement in CKD (QICKD) trial results.Kidney international · 2013Trial
- Article
- Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS.Journal of the American Heart Association · 2025Article
- Prevalence and pattern of multimorbidity among chronic kidney disease patients: a community study in chronic kidney disease hotspot area of Eastern India.Frontiers in medicine · 2023Article
- Performance of the SCORE and Globorisk cardiovascular risk prediction models: a prospective cohort study in Dutch general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Multimorbidity and statin prescription for primary prevention of cardiovascular diseases: A cross-sectional study in general practice in France.Frontiers in medicine · 2022Article
- Association between cardiometabolic disease multimorbidity and all-cause mortality in 2 million women and men registered in UK general practices.BMC medicine · 2021Article
- Sit less and move more for cardiovascular health: emerging insights and opportunities.Nature reviews. Cardiology · 2021Review
- Risk Factor Clusters and Cardiovascular Disease in High-Risk Patients: The UCC-SMART Study.Global heart · 2021Article
- Increased Medical Visits and Mortality among Adults with Cardiovascular Diseases in Severely Affected Areas after Typhoon Morakot.International journal of environmental research and public health · 2020Article
- Article
- Effect of multimorbidity on survival of patients diagnosed with heart failure: a retrospective cohort study in Singapore.BMJ open · 2018Article
- Prognosis of patients with apparent treatment-resistant hypertension-a feasibility study.Pilot and feasibility studies · 2018Article
- Association between multiple chronic conditions and urolithiasis.International urology and nephrology · 2017Article
- The burden of cardiovascular morbidity in a European Mediterranean population with multimorbidity: a cross-sectional study.BMC family practice · 2016Article
- Hypertension: a cross-sectional study of the role of multimorbidity in blood pressure control.BMC family practice · 2015Article
- Care in the last year of life for community patients with heart failure.Circulation. Heart failure · 2015Article
- A patient perspective of pharmacist prescribing: 'crossing the specialisms-crossing the illnesses'.Health expectations : an international journal of public participation in health care and health policy · 2015Article
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Authors and funding
7 authors.
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Abstract
backgroundMost patients managed in primary care have more than one condition. Multimorbidity presents challenges for the patient and the clinician, not only in terms of the process of care, but also in terms of management and risk assessment.
aimTo examine the effect of the presence of chronic kidney disease and diabetes on mortality and morbidity among patients with established cardiovascular disease. DESIGN OF STUDY: Retrospective cohort study.
settingRandom selection of 35 general practices in the west of Ireland.
methodA practice-based sample of 1609 patients with established cardiovascular disease was generated in 2000-2001 and followed for 5 years. The primary endpoint was death from any cause and the secondary endpoint was a cardiovascular composite endpoint that included death from a cardiovascular cause or any of the following cardiovascular events: myocardial infarction, heart failure, peripheral vascular disease, or stroke.
resultsRisk of death from any cause was significantly increased in patients with increased multimorbidity (P<0.001), as was the risk of the cardiovascular composite endpoint (P<0.001). Patients with cardiovascular disease and diabetes had a similar survival pattern to those with cardiovascular disease and chronic kidney disease, but experienced more cardiovascular events.
conclusionLevel of multimorbidity is an independent predictor of prognosis among patients with established cardiovascular disease. In such patients, the presence of chronic kidney disease carries a similar mortality risk to diabetes. Multimorbidity may be a useful factor in prioritising management of patients in the community with significant cardiovascular risk.
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