ArticleBMC pulmonary medicine2008
Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury.
Article in BMC pulmonary medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Hypertonic saline for traumatic brain injury: a systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study.Intensive care medicine experimental · 2021Article
- Protective Role of Angiotensin II Type 1 Receptor Blocker on Short Time Effect of Oleic Acid Induced Lung and Kidney Injury.International journal of preventive medicine · 2021Article
- Dual hit lipopolysaccharide & oleic acid combination induced rat model of acute lung injury/acute respiratory distress syndrome.The Indian journal of medical research · 2016Article
- Lung ultrasound is a reliable method for evaluating extravascular lung water volume in rodents.BMC anesthesiology · 2015Article
- Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs.Clinics (Sao Paulo, Brazil) · 2015Article
- The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats.Journal of anesthesia · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung injury is not known. We investigated the potential for hypertonic saline to modulate the evolution and resolution of oleic acid induced lung injury.
methodsAdult male Sprague Dawley rats were used in all experiments. Series 1 examined the potential for HTS to reduce the severity of evolving oleic acid (OA) induced acute lung injury. Following intravenous OA administration, animals were randomized to receive isotonic (Control, n = 12) or hypertonic saline (HTS, n = 12), and the extent of lung injury assessed after 6 hours. Series 2 examined the potential for HTS to enhance the resolution of oleic acid (OA) induced acute lung injury. Following intravenous OA administration, animals were randomized to receive isotonic (Control, n = 6) or hypertonic saline (HTS, n = 6), and the extent of lung injury assessed after 6 hours.
resultsIn Series I, HTS significantly reduced bronchoalveolar lavage (BAL) neutrophil count compared to Control [61.5 +/- 9.08 versus 102.6 +/- 11.89 x 10(3) cells.ml-1]. However, there were no between group differences with regard to: A-a O2 gradient [11.9 +/- 0.5 vs. 12.0 +/- 0.5 KPa]; arterial PO2; static lung compliance, or histologic injury. In contrast, in Series 2, hypertonic saline significantly reduced histologic injury and reduced BAL neutrophil count [24.5 +/- 5.9 versus 46.8 +/- 4.4 x 10(3) cells.ml-1], and interleukin-6 levels [681.9 +/- 190.4 versus 1365.7 +/- 246.8 pg.ml-1].
conclusionThese findings demonstrate, for the first time, the potential for HTS to reduce pulmonary inflammation and enhance the resolution of oleic acid induced lung injury.
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