ArticleBMC genetics2008
Population-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.Human molecular genetics · 2016Pooled it
- Familial risk of placental abruption.European journal of obstetrics, gynecology, and reproductive biology · 2026Article
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Changing risk factors for placental abruption: A case crossover study using routinely collected data from Finland, Malta and Aberdeen.PloS one · 2020Article
- Assessing the risk factors before pregnancy of preterm births in Iran: a population-based case-control study.BMC pregnancy and childbirth · 2019Article
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Determinants of preterm birth at Jimma University Medical Center, southwest Ethiopia.Pediatric health, medicine and therapeutics · 2018Article
- Racial and ethnic differences in preterm birth: A complex, multifactorial problem.Seminars in perinatology · 2017Review
- Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population.Pediatric research · 2017Article
- Reduced CRHR-2 in placental tissues is associated with the high DNA methylation of CRHR-2 promoter in idiopathic preterm birth.International journal of clinical and experimental pathology · 2017Article
- Maternal and neonatal epidemiological features in clinical subtypes of preterm birth.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2016Observational
- Pregnancy, parturition and preeclampsia in women of African ancestry.American journal of obstetrics and gynecology · 2014Review
- Pathway analysis of genetic factors associated with spontaneous preterm birth and pre-labor preterm rupture of membranes.PloS one · 2014Review
- Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity.American journal of perinatology · 2013Article
- Article
- An evolutionary genomic approach to identify genes involved in human birth timing.PLoS genetics · 2011Article
- A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).American journal of obstetrics and gynecology · 2010Article
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.American journal of obstetrics and gynecology · 2010Article
- Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2009Article
- Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth.Human heredity · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse pregnancy outcomes, such as preterm birth, preeclampsia and placental abruption, are common, with acute and long-term complications for both the mother and infant. Etiologies underlying such adverse outcomes are not well understood. As maternal and fetal genetic factors may influence these outcomes, we estimated the magnitude of familial aggregation as one index of possible heritable contributions. Using the Missouri Department of Health's maternally-linked birth certificate database, we performed a retrospective population-based cohort study of births (1989-1997), designating an individual born from an affected pregnancy as the proband for each outcome studied. We estimated the increased risk to siblings compared to the population risk, using the sibling risk ratio, lambdas, and sibling-sibling odds ratio (sib-sib OR), for the adverse pregnancy outcomes of preterm birth, preterm premature rupture of membranes (PPROM), placental abruption, and pre-eclampsia.
resultsRisk to siblings of an affected individual was elevated above the population prevalence of a given disorder, as indicated by lambdaS (lambdaS (95% CI): 4.3 (4.0-4.6), 8.2 (6.5-9.9), 4.0 (2.6-5.3), and 4.5 (4.4-4.8), for preterm birth, PPROM, placental abruption, and pre-eclampsia, respectively). Risk to siblings of an affected individual was similarly elevated above that of siblings of unaffected individuals, as indicated by the sib-sib OR (sib-sib OR adjusted for known risk factors (95% CI): 4.2 (3.9-4.5), 9.6 (7.6-12.2), 3.8 (2.6-5.5), 8.1 (7.5-8.8) for preterm birth, PPROM, placental abruption, and pre-eclampsia, respectively).
conclusionThese results suggest that the adverse pregnancy outcomes of preterm birth, PPROM, placental abruption, and pre-eclampsia aggregate in families, which may be explained in part by genetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.