ArticleJournal of the American Chemical Society2008
Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Beyond photobleaching: radical-driven photocleavage and destaining mechanisms in chromophore-biomolecule conjugates.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Ultrafast Electron Dynamics of a Ferrocene-Based Butadiyne-Bridged Complex.The journal of physical chemistry. A · 2026Article
- Twisted molecular wires polarize spin currents at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Driving high quantum yield NIR emission through proquinoidal linkage motifs in conjugated supermolecular arrays.Chemical science · 2020Article
- Engineering Polymersomes for Diagnostics and Therapy.Advanced healthcare materials · 2018Review
- NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.Nanoscale · 2017Article
- Progressive Saturation Improves the Encapsulation of Functional Proteins in Nanoscale Polymer Vesicles.Pharmaceutical research · 2016Article
- Retaining individualities: the photodynamics of self-ordering porphyrin assemblies.Chemical communications (Cambridge, England) · 2016Article
- Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imagingBiotechnology, biotechnological equipment · 2015Article
- Article
- Fluorescent nanoprobes dedicated to in vivo imaging: from preclinical validations to clinical translation.Molecules (Basel, Switzerland) · 2012Review
- Sensing membrane stress with near IR-emissive porphyrins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A Generalized System for Photo-Responsive Membrane Rupture in Polymersomes.Advanced functional materials · 2010Article
- One- and two-photon absorption of highly conjugated multiporphyrin systems in the two-photon Soret transition region.The Journal of chemical physics · 2009Article
- Photoinitiated destruction of composite porphyrin-protein polymersomes.Journal of the American Chemical Society · 2009Article
- In vivo fluorescence imaging: a personal perspective.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
5 authors.
Funding
Abstract
Formed through cooperative self-assembly of amphiphilic diblock copolymers and electronically conjugated porphyrinic near-infrared (NIR) fluorophores (NIRFs), NIR-emissive polymersomes (50 nm to 50 microm diameter polymer vesicles) define a family of organic-based, soft-matter structures that are ideally suited for deep-tissue optical imaging and sensitive diagnostic applications. Here, we describe magic angle and polarized pump-probe spectroscopic experiments that: (i) probe polymersome structure and NIRF organization and (ii) connect emitter structural properties and NIRF loading with vesicle emissive output at the nanoscale. Within polymersome membrane environments, long polymer chains constrain ethyne-bridged oligo(porphinato)zinc(II) based supermolecular fluorophore (PZn n ) conformeric populations and disperse these PZn n species within the hydrophobic bilayer. Ultrafast excited-state transient absorption and anisotropy dynamical studies of NIR-emissive polymersomes, in which the PZn n fluorophore loading per nanoscale vesicle is varied between 0.1-10 mol %, enable the exploration of concentration-dependent mechanisms for nonradiative excited-state decay. These experiments correlate fluorophore structure with its gross spatial arrangement within specific nanodomains of these nanoparticles and reveal how compartmentalization of fluorophores within reduced effective dispersion volumes impacts bulk photophysical properties. As these factors play key roles in determining the energy transfer dynamics between dispersed fluorophores, this work underscores that strategies that modulate fluorophore and polymer structure to optimize dispersion volume in bilayered nanoscale vesicular environments will further enhance the emissive properties of these sensitive nanoscale probes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.