ArticleWorld journal of gastroenterology2008
Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.The Journal of surgical research · 2019Trial
- Gut Microbial Dysbiosis and Implications in Solid Organ Transplantation.Biomedicines · 2024Review
- The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations.Infection · 2024Review
- Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.Gut and liver · 2021Review
- Current Status and Prospects of Spontaneous Peritonitis in Patients with Cirrhosis.BioMed research international · 2020Review
- Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats.Gastroenterology research and practice · 2019Article
- Changes of Intestinal Functions in Liver Cirrhosis.Inflammatory intestinal diseases · 2016Review
- Gut epithelial barrier dysfunction in human immunodeficiency virus-hepatitis C virus coinfected patients: Influence on innate and acquired immunity.World journal of gastroenterology · 2016Review
- Intestinal permeability in a patient with liver cirrhosis.Therapeutics and clinical risk management · 2016Review
- Low risk of bacteremia after endoscopic variceal therapy for esophageal varices: a systematic review and meta-analysis.Endoscopy international open · 2015Review
- Baicalein reduces the occurrence of cirrhotic endotoxemia by reducing intestinal mucosal apoptosis.BMC complementary and alternative medicine · 2015Article
- Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia.World journal of hepatology · 2015Review
- Intestinal permeability--a new target for disease prevention and therapy.BMC gastroenterology · 2014Review
- Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.Therapeutic advances in infectious disease · 2014Article
- Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?Clinical and experimental gastroenterology · 2012Article
- Enterocytes' tight junctions: From molecules to diseases.World journal of gastrointestinal pathophysiology · 2011Article
- Non-invasive assessment of barrier integrity and function of the human gut.World journal of gastrointestinal surgery · 2010Article
- Acute Variceal Bleed in Cirrhosis is Associated With Reversible Changes in Tight Junction Protein Expression in the Intestine: A Proof-of-Concept Study.Journal of clinical and experimental hepatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
aimTo determine intestinal permeability, the serum tumor necrosis factor (TNF)-alpha level and urine nitric oxide (NO) metabolites are altered in liver cirrhosis (LC) with or without ascites.
methodsFifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol (PEG) 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-alpha concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay (ELISA) and Greiss reaction method, respectively.
resultsThe intestinal permeability index was significantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites (0.88 +/- 0.12 vs 0.52 +/- 0.05 or 0.53 +/- 0.03, P < 0.05) and correlated with urine nitrite excretion (r = 0.98). Interestingly, the serum TNF-alpha concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites (198.9 +/- 55.8 pg/mL vs 40.9 +/- 12.3 pg/mL or 32.1 +/- 13.3 pg/mL, P < 0.05). Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites (1170.9 +/- 28.7 micromol/L vs 903.1 +/- 55.1 micromol/L or 956.7 +/- 47.7 micromol/L, P < 0.05).
conclusionIncreased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-alpha concentration was not related to LC with ascites.
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Registered trials
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