ArticleWorld journal of gastroenterology2008
Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: open label study.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Precision medicine in intestinal ischemia: the emerging role of biomarkers.Internal and emergency medicine · 2025Review
- Diagnostic methods and drug therapies in patients with ischemic colitis.International journal of colorectal disease · 2021Review
- Predictors of severity in ischaemic colitis.International journal of colorectal disease · 2012Article
- Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution.World journal of gastroenterology · 2011Article
- Wound healing of intestinal epithelial cells.World journal of gastroenterology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo attempt rectal administration of rebamipide in the treatment of ischemic colitis patients with ulcers, and evaluate its effects.
methodsWe compared 9 ischemic colitis patients (2 men, 7 women) with ulcers treated by bowel rest only from 2000 to 2005 (conventional therapy group), with 6 patients (2 men, 4 women) treated by rebamipide enema therapy in 2006 (rebamipide enema therapy group) and analyzed the mean duration of fasting and hospitalization, degree of ulcer healing, and decrease in WBC count for the two groups.
resultsThe mean duration of fasting and hospitalization were 2.7+/-1.8 d and 9.2+/-1.5 d in the rebamipide group and 7.9+/-4.1 d and 17.9+/-6.8 d in the control group, respectively, and significantly reduced in the rebamipide group (t= -2.915; P=0.0121 and t= -3.054; P=0.0092). As for the degree of ulcer healing at 7 d after admission, the ulcer score was reduced by 3.5+/-0.5 (points) in the rebamipide group and 2.8+/-0.5 (points) in the control group (t=1.975; P=0.0797), while the decrease in WBC count was 120.0+/-55.8 (x 10(2)/microL) in the rebamipide group and 85.9+/-56.8 (x 10(2)/microL) in the control group (t=1.006; P=0.3360).
conclusionIn left-sided ischemic colitis patients with ulcers, rebamipide enema therapy significantly reduced the duration of fasting and hospitalization, recommending its use as a new and effective therapeutic alternative.
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