ArticleStress (Amsterdam, Netherlands)2008
Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams.
Article in Stress (Amsterdam, Netherlands), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Ontogenic, Immunological, and Behavioral Changes of Crack Cocaine Exposure During the Gestational Period.Molecular neurobiology · 2025Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Prenatal substance exposure, early-life adversity, and parenting: Associations with adolescent stress response.Developmental psychobiology · 2023Article
- The Role of Oxytocin and Vasopressin in Drug-Induced Reward-Implications for Social and Non-Social Factors.Biomolecules · 2023Review
- Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats.IBRO neuroscience reports · 2021Article
- Oxycodone self-administration during pregnancy disrupts the maternal-infant dyad and decreases midbrain OPRM1 expression during early postnatal development in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Genes and Aggressive Behavior: Epigenetic Mechanisms Underlying Individual Susceptibility to Aversive Environments.Frontiers in behavioral neuroscience · 2018Review
- Cocaine-induced neurodevelopmental deficits and underlying mechanisms.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Prenatal cocaine exposure and trajectories of externalizing behavior problems in early childhood: examining the role of maternal negative affect.Development and psychopathology · 2014Article
- Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction.Pharmacology, biochemistry, and behavior · 2014Review
- Externalizing behavior problems among polydrug cocaine-exposed children: Indirect pathways via maternal harshness and self-regulation in early childhood.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2014Article
- Effect of prenatal cocaine on early postnatal thermoregulation and ultrasonic vocalization production.Frontiers in psychology · 2013Article
- Chronic cocaine exposure during pregnancy increases postpartum neuroendocrine stress responses.Journal of neuroendocrinology · 2012Article
- Effects of cocaine on maternal behavior and neurochemistry.Current neuropharmacology · 2012Article
- Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure.Current neuropharmacology · 2011Article
- Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat.Synapse (New York, N.Y.) · 2011Article
- The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior.Neuroscience and biobehavioral reviews · 2011Review
- Combined norepinephrine/serotonergic reuptake inhibition: effects on maternal behavior, aggression, and oxytocin in the rat.Frontiers in psychiatry · 2011Article
- Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems.Frontiers in psychiatry · 2011Article
- Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol.Frontiers in psychiatry · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12. Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.