ArticleStress (Amsterdam, Netherlands)2008
Angiotensin II AT(1) receptor blockade selectively enhances brain AT(2) receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats.
Article in Stress (Amsterdam, Netherlands), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prostaglandin EThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Enhancing Fear Extinction: Pharmacological Approaches.Current topics in behavioral neurosciences · 2023Article
- The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.Cellular and molecular neurobiology · 2022Article
- Inhibition of angiotensin II type 1 receptor by candesartan reduces tumor growth and ameliorates fibrosis in colorectal cancer.EXCLI journal · 2021Article
- Augmentation of Extinction and Inhibitory Learning in Anxiety and Trauma-Related Disorders.Annual review of clinical psychology · 2019Review
- Dysregulation of the Renin-Angiotensin System and the Vasopressinergic System Interactions in Cardiovascular Disorders.Current hypertension reports · 2018Review
- Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli.Cellular and molecular neurobiology · 2018Review
- AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats.Cellular and molecular neurobiology · 2018Article
- Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen.CNS neuroscience & therapeutics · 2016Article
- Angiotensin type 1 receptor inhibition enhances the extinction of fear memory.Biological psychiatry · 2014Article
- The link between stress disorders and autonomic dysfunction in muscular dystrophy.Frontiers in physiology · 2014Article
- The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases.Pflugers Archiv : European journal of physiology · 2013Review
- Angiotensin II AT₁ receptors are involved in neuronal activation induced by amphetamine in a two-injection protocol.BioMed research international · 2013Article
- Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders.Clinical science (London, England : 1979) · 2012Review
- Ontogeny of angiotensin type 2 and type 1 receptor expression in mice.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2012Article
- Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders.Cellular and molecular neurobiology · 2012Review
- Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress.Behavioural brain research · 2012Article
- Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications.Psychoneuroendocrinology · 2011Review
- Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice.Regulatory peptides · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated orally for 14 days with the AT(1) receptor antagonist candesartan before submission to 2 h of cold-restraint stress. In non-treated rats, stress decreased AT(1) receptor binding in the median eminence and basolateral amygdala, increased AT(2) receptor binding in the medial subnucleus of the inferior olive, decreased AT(2) binding in the ventrolateral thalamic nucleus and increased tyrosine hydroxylase mRNA level in the locus coeruleus. In non-stressed rats, AT(1) receptor blockade reduced AT(1) receptor binding in all areas studied and enhanced AT(2) receptor binding in the medial subnucleus of the inferior olive. Candesartan pretreatment produced a similar decrease in brain AT(1) binding after stress, and prevented the stress-induced AT(2) receptor binding decrease in the ventrolateral thalamic nucleus. In the locus coeruleus and adrenal medulla, AT(1) blockade abolished the stress-induced increase in tyrosine hydroxylase mRNA level. Our results demonstrate that oral administration of candesartan effectively blocked brain AT(1) receptors, selectively increased central AT(2) receptor expression and prevented the stress-induced central stimulation of tyrosine hydroxylase transcription. The present results support a role of brain AT(1) and AT(2) receptors in the regulation of the stress response, and the hypothesis that AT(1) receptor antagonists may be considered as potential therapeutic compounds in stress related disorders in addition to their anti-hypertensive properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.