ReviewMicrocirculation (New York, N.Y. : 1994)2008
Theoretical models of microvascular oxygen transport to tissue.
Review in Microcirculation (New York, N.Y. : 1994), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed.
- FLASH radiotherapy: physico-chemical considerations on ionisation tracks, radical reactions, and the role of oxygen.Radiation oncology (London, England) · 2026Review
- Bridging tumor biology and radiomics through an ultra-large physics-driven vascular model.npj biomedical innovations · 2026Article
- Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model.The Journal of physiology · 2026Review
- Abnormal vasculature reduces overlap between drugs and oxygen in a tumour computational model: Implications for therapeutic efficacy.PLoS computational biology · 2025Article
- Modeling of Singlet Oxygen Generation and Thermal Effects During Laser-Tissue Interaction.Materials (Basel, Switzerland) · 2025Article
- A theoretical model for oxygen transport to the cerebral cortex: effects of flow redistribution by penetrating arterioles.Microvascular research · 2025Article
- Sensitivity Analysis in the Problem of the Impact of an External Heat Impulse on Oxygen Distribution in Biological Tissue.Materials (Basel, Switzerland) · 2025Article
- A computational algorithm for optimal design of a bioartificial organ scaffold architecture.PLoS computational biology · 2024Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma.PLoS computational biology · 2024Article
- Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Simulating photodynamic therapy for the treatment of glioblastoma using Monte Carlo radiative transport.Journal of biomedical optics · 2024Article
- The coronary capillary bed and its role in blood flow and oxygen delivery: A review.Anatomical record (Hoboken, N.J. : 2007) · 2022Review
- Baseline oxygen consumption decreases with cortical depth.PLoS biology · 2022Article
- Modeling the Effect of Hyperoxia on the Spin-Lattice Relaxation Rate R1 of Tissues.Magnetic resonance in medicine · 2022Article
- Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging.Frontiers in aging neuroscience · 2022Review
- A Mesoscale Computational Model for Microvascular Oxygen Transfer.Annals of biomedical engineering · 2021Article
- Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties.The Journal of physiology · 2021Article
- Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo.International journal of radiation oncology, biology, physics · 2021Article
- Article
9 more citing papers are in PubMed but not listed here.
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1 author.
Funding
Abstract
To improve understanding of microvascular O(2) transport, theoretical modeling has been pursued for many years. The large number of studies in this area attests to the complexities (i.e., biochemical, structural, and hemodynamic) involved. This article focuses on theoretical studies from the last two decades and, in particular, on models of O(2) transport to tissue by discrete microvessels. A brief discussion of intravascular O(2) transport is first given, highlighting the physiological importance of intravascular resistance to blood-tissue O(2) transfer. This is followed by a description of the Krogh tissue cylinder model of O(2) transport by a single capillary, which is shown to remain relevant in modified forms that relax many of the original biophysical assumptions. However, there are many geometric and hemodynamic complexities that require the consideration of microvascular arrays and networks. Multivessel models are discussed that have shown the physiological importance of heterogeneities in vessel spacing, O(2) supply, red blood cell flow path, as well as interactions between capillaries and arterioles. These realistic models require sophisticated methods for solving the governing partial differential equations, and a range of solution techniques are described. Finally, the issue of experimental validation of microvascular O(2) delivery models is discussed, and new directions in O(2) transport modeling are outlined.
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