ArticleJournal of clinical and experimental neuropsychology2008
An exploratory study of long-term neurocognitive outcomes following recovery from opportunistic brain infections in HIV+ adults.
Article in Journal of clinical and experimental neuropsychology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Early Antiretroviral Therapy in AIDS Patients Presenting WithFrontiers in medicine · 2022Article
- Outcome of Lenalidomide Treatment for Cognitive Impairment Caused by Immune Reconstitution Inflammatory Syndrome in Patients with HIV-Related Cryptococcal Meningitis.Journal of inflammation research · 2022Article
- Lenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis.Journal of inflammation research · 2022Article
- Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis.Clinical microbiology reviews · 2021Review
- Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia).Epidemiology and infection · 2020Article
- HIV-Negative Cryptococcal Meningoencephalitis Results in a Persistent Frontal-Subcortical Syndrome.Scientific reports · 2019Observational
- Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis.Wellcome open research · 2019Review
- Human Immunodeficiency Virus in the Brain-Culprit or Facilitator?Infectious diseases · 2018Review
- Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts.BMC neurology · 2017Article
- Neurobehavioral Manifestations of Human Immunodeficiency Virus/AIDS: Diagnosis and Treatment.Neurologic clinics · 2016Review
- Cognitive impairment in patients with AIDS - prevalence and severity.HIV/AIDS (Auckland, N.Z.) · 2015Review
- Predictors of neurocognitive outcomes on antiretroviral therapy after cryptococcal meningitis: a prospective cohort study.Metabolic brain disease · 2014Article
- An algorithmic approach to structural imaging in dementia.Journal of neurology, neurosurgery, and psychiatry · 2014Review
- Neurocognitive impairment in HIV-infected individuals with previous syphilis.International journal of STD & AIDS · 2013Observational
- Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.AIDS (London, England) · 2012Article
- Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders.Journal of neurovirology · 2012Article
- Neuropsychological evaluation and follow up in jcv- and non-jcv-related leukoencephalopathies in HIV infection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Article
- Neurologic presentations of AIDS.Neurologic clinics · 2010Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Central nervous system opportunistic infections (CNS-OI) are a significant cause of morbidity and mortality in AIDS. While current interventions are increasingly successful in treating CNS-OI, little information exists regarding long-term behavioral outcomes among survivors. In this exploratory study we examined neurocognitive data among three groups of adults with different AIDS-related CNS-OI: 15 with past cryptococcal meningitis (CM), 8 with toxoplasmosis encephalitis (TE), and 8 with progressive multifocal leukoencephalopathy (PML). A group of 61 individuals with AIDS, but without CNS-OI, was used as a comparison group. A battery of standardized neuropsychological tests assessing a variety of cognitive domains was administered upon entry. Results indicate that individuals with a history of CNS-OI were most impaired on measures of cognitive and psychomotor speed relative to the HIV+ comparison group. Among the CNS-OI groups, individuals with history of TE had the most severe and varied deficits. The results are discussed in relation to what is known about the neuropathological consequences of the various CNS-OIs. While this is the first systematic group study of residual CNS-OI effects on neurocognitive function, future studies employing more participants, perhaps focusing on specific CNS-OIs, will further characterize the long-term outcomes in AIDS-related CNS-OI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.