ArticleNeuroscience and behavioral physiology2008
Interaction of the postsynaptic effects of glycine and GABA on spinal cord neurons in the frog Rana temporaria.
Article in Neuroscience and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 3 citations in OpenAlex.
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2 authors at 2 institutions in 1 country.
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Abstract
Studies were performed on mechanically isolated spinal cord multipolar cells (presumptive motoneurons) from the frog Rana temporaria using patch-clamp methods in the whole-cell configuration. These experiments showed that the amplitudes of transmembrane currents arising in response to simultaneous application of GABA and glycine were smaller than the sums of the amplitudes of the responses of the same neurons to GABA and glycine applied individually. Investigation of the mechanisms of this occlusion showed that superfusion of neurons with glycine solution (0.2 mM) resulted in complete blockade of responses to application of GABA (5 mM) and vice versa. This phenomenon may have resulted from cross-blockade associated with the existence of a single receptor complex sensitive to both GABA and glycine and from the interaction of GABA and glycine receptors.
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