Evidence map›Paper›PMID 18607697›Full record

ArticleJournal of fluorescence2009

Studies on interaction of CdTe quantum dots with bovine serum albumin using fluorescence correlation spectroscopy.

Liwen Shao, Chaoqing Dong, Fuming Sang, Huifeng Qian, Jicun Ren

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Article in Journal of fluorescence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liwen ShaoCollege of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China.
Chaoqing Dong
Fuming Sang
Huifeng Qian
Jicun Ren

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luminescent quantum dots (QDs) have widely used in some biological and biomedical fields due to their unique and fascinating optical properties, meanwhile the interaction of QDs with biomolecules recently attract increasing attention. In this paper, we employed fluorescence correlation spectroscopy (FCS) to investigate the nonspecific interaction between CdTe QDs and bovine serum albumin (BSA) as a model, and evaluate their stoichiometric ratio and association constant. Our results documented that BSA was able to bind to CdTe QDs and form the QD-BSA complex by a 1:1 stoichiometric ratio. The association constant evaluated is 1.06+/-0.14x10(7) M(-1) in 0.01 M phosphate buffer (pH=7.4). Furthermore, we found that QD-BSA complex dissociated with increase of ion strength, and we speculated that the interaction of CdTe QDs with BSA was mainly attributed to electrostatic attraction. Our preliminary results demonstrate that fluorescence correlation spectroscopy is an effective tool for investigation of the interaction between quantum dots (or nanoparticles) and biomolecules.

Indexed as

Quantum DotsCadmium CompoundsLuminescent MeasurementsOsmolar ConcentrationSensitivity and SpecificitySerum Albumin, BovineSodium ChlorideSpectrometry, FluorescenceTelluriumCadmium Compoundscadmium tellurideSerum Albumin, BovineSodium ChlorideTellurium

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.