ArticlePharmaceutical research2008
Methods to account for inaccuracies in the dosing history when performing population pharmacokinetic analysis.
Article in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Pharmacokinetic analysis across studies to drive knowledge-integration: A tutorial on individual patient data meta-analysis (IPDMA).CPT: pharmacometrics & systems pharmacology · 2023Article
- Challenges faced when modeling clinical toxicology and toxinology events.CPT: pharmacometrics & systems pharmacology · 2022Article
- Approaches to handling missing or "problematic" pharmacology data: Pharmacokinetics.CPT: pharmacometrics & systems pharmacology · 2021Article
- Handling Missing Dosing History in Population Pharmacokinetic Modeling: An Extension to MDM Method.CPT: pharmacometrics & systems pharmacology · 2019Article
- The pharmacokinetics of sertraline in overdose and the effect of activated charcoal.British journal of clinical pharmacology · 2015Article
- Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal.British journal of clinical pharmacology · 2012Article
- Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling.European journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop and assess methods to account for missing dose history (MDH).
methodsA simulation study was performed with different doses, dose times and formulations using NONMEM. Four methods were used to account for MDH, these were the ideal dose method (IDM) which uses the actual dose history, the concentration minimum method (CMM) which assumes that the nominal dose history is accurate, the extrapolation subtraction method (ESM) which estimates the residual concentration at the time of the study dose and the concentration time method (CTM) where the time of the previous dose event is estimated. The CTM is a new method.
resultsThe CTM was superior to ESM and CMM and provided parameter estimates that were comparable in accuracy to the IDM.
conclusionsWhen the nominal dosing history is available then the CTM is a simple and effective method to account for potential inaccuracies in the dose history.
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