Evidence map›Paper›PMID 18607668›Full record

ArticleCerebellum (London, England)2008

Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.

Sho Kakizawa, Shigeki Moriguchi, Atsushi Ikeda, Masamitsu Iino, Hiroshi Takeshima

Abstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  5. ER-PM Contact Sites - SNARING Actors in Emerging Functions.Frontiers in cell and developmental biology · 2021
    Review
  6. Targeting JP2: A New Treatment for Pulmonary Hypertension.Oxidative medicine and cellular longevity · 2021
    Review
  7. Junctophilins: Key Membrane Tethers in Muscles and Neurons.Frontiers in molecular neuroscience · 2021
    Review
  8. Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Lipid transporter TMEM24/C2CD2L is a CaProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. TheDisease models & mechanisms · 2018
    Article
  11. Article
  12. Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015
    Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sho KakizawaDepartment of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shigeki Moriguchi
Atsushi Ikeda
Masamitsu Iino
Hiroshi Takeshima
Kyoto University · JPThe University of Tokyo · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

Indexed as

AnimalsCell MembraneCerebellumEndoplasmic ReticulumHippocampusLearning DisabilitiesMammalsMembrane ProteinsMemory DisordersMiceMice, KnockoutMuscle ContractionMuscle, SkeletalNerve Tissue ProteinsNeuronal PlasticityNeuronsJph4 protein, mousejunctophilinMembrane ProteinsNerve Tissue Proteins

Identifiers

PMID18607668
OpenAlexW1974081341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.