SynthesisWorld journal of urology2009
Penile cancer: epidemiology, pathogenesis and prevention.
Synthesis in World journal of urology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma
Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC): an Open-label, Single-center, Phase 2, Single-arm Trial (CaboPen)
Who cites it
111 citing papers in PubMed, 3 syntheses or guidelines pooled it, 362 citations in OpenAlex.
- Human papillomavirus (HPV) vaccination for the prevention of cervical cancer and other HPV-related diseases: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature.International journal of environmental research and public health · 2021Pooled it
- Penile cancer: Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2013Guideline
- Low-dose brachytherapy for early stage penile cancer: a 20-year single-institution study (73 patients).Radiation oncology (London, England) · 2016Trial
- Phase II study of docetaxel, cisplatin, and fluorouracil in patients with distantly metastatic penile cancer as first-line chemotherapy.Oncotarget · 2015Trial
- Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Trial
- Penile human papilloma virus (HPV) in high risk populations with and without HIV: Epidemiological insights from Argentina.International journal of STD & AIDS · 2026Article
- Pseudoepitheliomatous hyperplasia of the prepuce, a benign mimic of penile squamous cell carcinoma: a case report.Journal of medical case reports · 2026Article
- Efficacy and safety of tislelizumab combined with chemotherapy for locally advanced penile cancer: a prospective, single-arm clinical study.British journal of cancer · 2026Article
- Penile squamous cell carcinoma masquerading as Fournier's Gangrene: A case of a young patient with aggressive, metastatic disease.Urology case reports · 2026Article
- The Presentation and Treatment of Myointimoma: A Systematic Review and the First Case Report of Penile Myointimoma as a Cause of Urethral Obstruction.Journal of clinical medicine · 2026Review
- [Treatment options in rare urological tumors: potential of molecular tumor boards].Urologie (Heidelberg, Germany) · 2026Review
- Extranodal Male Genital Involvement With Diffuse Large B-Cell Lymphoma.Case reports in hematology · 2026Article
- Temporal trends in long-term relative survival of cutaneous verrucous carcinoma: a period analysis from a large-scale SEER-based cohort.Frontiers in medicine · 2026Article
- Review
- Penile squamous cell carcinoma with posterior urethra involvement: A case report.Radiology case reports · 2025Article
- [Pathology and molecular pathology of carcinoma of the penis].Pathologie (Heidelberg, Germany) · 2025Review
- Transcriptionally Active Human Papillomavirus in Male Genital Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma.JID innovations : skin science from molecules to population health · 2025Article
- Immune checkpoint inhibitor therapy for advanced HPV-related penile squamous cell carcinoma: a rare case report.Frontiers in oncology · 2025Article
- Exploring the Multifactorial Landscape of Penile Cancer: A Comprehensive Analysis of Risk Factors.Diagnostics (Basel, Switzerland) · 2024Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPenile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer and discusses the molecular pathogenesis, including the role of HPV in penile cancer development.
methodsA systematic review of the literature evaluating penile carcinogenesis, risk factors and molecular mechanisms involved.
resultsCareful monitoring of men with lichen sclerosis, genital Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis seems useful, thereby offering early recognition of penile cancer and, subsequently, conservative therapeutic options. Special attention is given to flat penile lesions, which contain high numbers of HPV. Their role in HPV transmission to sexual partners is highlighted, but their potential to transform as a precursor lesion into penile cancer has been unsatisfactorily explored.
conclusionsFurther research should not only focus on HPV mediated pathogenic pathways but also on the non-HPV related molecular and genetic factors that play a role in penile cancer development. Options for prevention of penile cancer include (neonatal) circumcision, limitation of penile HPV infections (either by prophylactic vaccination or condom use), prevention of phimosis, treatment of chronic inflammatory conditions, limiting PUVA treatment, smoking cessation and hygienic measures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.