Trial reportIntensive care medicine2008
Nasal continuous positive airway pressure decreases respiratory muscles overload in young infants with severe acute viral bronchiolitis.
Trial report in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Continuous positive airway pressure (CPAP) for acute bronchiolitis in children.The Cochrane database of systematic reviews · 2022Pooled it
- Continuous positive airway pressure (CPAP) for acute bronchiolitis in children.The Cochrane database of systematic reviews · 2019Pooled it
- Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC).Intensive care medicine · 2017Guideline
- A multicenter randomized controlled trial of a 3-L/kg/min versus 2-L/kg/min high-flow nasal cannula flow rate in young infants with severe viral bronchiolitis (TRAMONTANE 2).Intensive care medicine · 2018Trial
- High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).Intensive care medicine · 2017Trial
- Clinical Interventions During Inter-hospital Transfer of Infants With Moderate-to-Severe Bronchiolitis: Implications for Advanced Nursing Practice.Nursing in critical care · 2026Observational
- Review
- Helmet Continuous Positive Airway Pressure for Acute Bronchiolitis Respiratory Failure in a Pediatric Ward: Is It a Replicable Experience?Children (Basel, Switzerland) · 2024Article
- Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome.Diseases (Basel, Switzerland) · 2024Article
- Bubble Continuous Positive Airway Pressure Oxygen Therapy in Children Under Five Years of Age with Respiratory Distress in Pediatric Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Safety and effectiveness of bubble continuous positive airway pressure as respiratory support for bronchiolitis in a pediatric ward.European journal of pediatrics · 2022Observational
- High-Flow Nasal Cannula versus Continuous Positive Airway Pressure in Critical Bronchiolitis: A Randomized Controlled Pilot.Journal of pediatric intensive care · 2020Article
- Pediatric respiratory distress: California out-of-hospital protocols and evidence-based recommendations.Journal of the American College of Emergency Physicians open · 2020Article
- [Predictive factors for failure of continuous positive airway pressure treatment in infants with bronchiolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- High-flow oxygen therapy v. standard care in infants with viral bronchiolitis.The Southern African journal of critical care : the official journal of the Critical Care Society · 2020Article
- Comparison of Effort of Breathing for Infants on Nasal Modes of Respiratory Support.The Journal of pediatrics · 2017Article
- [Noninvasive ventilation in pediatric acute respiratory failure].Notfall & rettungsmedizin · 2017Review
- Comparison of a high-flow humidified nasal cannula to nasal continuous positive airway pressure in children with acute bronchiolitis: experience in a pediatric intensive care unit.European journal of pediatrics · 2014Article
- Continuous positive airway pressure for bronchiolitis in a general paediatric ward; a feasibility study.BMC pediatrics · 2014Article
- Acute bronchiolitis in infants, a review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the efficacy of nasal continuous positive airway pressure (nCPAP) on respiratory distress symptoms and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis.
designProspective study.
settingThe paediatric intensive care unit of a university hospital. PATIENTS: Twelve infants less than 3 months of age, with severe respiratory distress.
interventionsRespiratory distress was quantified with a specific scoring system. Oesophageal pressure (Pes) was measured during spontaneous ventilation before and after nCPAP, delivered through an infant-adapted ventilator. Simultaneous recording of gastric pressure (Pgas) was performed in the five oldest patients. MEASUREMENTS AND
resultsThe respiratory distress score decreased after nCPAP, particularly accessory muscles' use and expiratory wheezing. The breathing pattern was modified, with shorter inspiratory and longer expiratory time. Pes swings and PTPes(insp), two indices of inspiratory effort, were reduced by 54 (+/-4)% and 59 (+/-5)%. PTPgas(exp), an indicator of expiratory muscles activity, was completely abolished. A significant correlation was observed between the respiratory distress score and Pes swings at baseline and after nCPAP.
conclusionsIn young infants with severe acute respiratory syncytial virus bronchiolitis, nCPAP rapidly unloads respiratory muscles and improves respiratory distress symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.