Trial reportSexually transmitted diseases2008
The influence of depression on sexual risk reduction and STD infection in a controlled, randomized intervention trial.
Trial report in Sexually transmitted diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions for encouraging sexual behaviours intended to prevent cervical cancer.The Cochrane database of systematic reviews · 2011Pooled it
- Patterns of Engagement With the mHealth Component of a Sexual and Reproductive Health Risk Reduction Intervention for Young People With Depression: Latent Trajectory Analysis.JMIR mHealth and uHealth · 2025Trial
- Added benefits: reduced depressive symptom levels among African-American female adolescents participating in an HIV prevention intervention.Journal of behavioral medicine · 2014Trial
- Clinical depression and HIV risk-related sexual behaviors among African-American adolescent females: unmasking the numbers.AIDS care · 2012Trial
- Depression increases the risk of contracting genital herpes and genital wart in U.S. adults: A cross-sectional analysis.Medicine · 2025Article
- Assessment of Sexual Risk Behavior and Mental Health Status Among Urban Slum Dwellers in Bangladesh: A Cross-Sectional Study.Health science reports · 2025Article
- The Increased Risk for HIV and Other Sexually Transmitted Infections Among Substance-Using and Depressed Women in the Legal System.Journal of healthcare, science and the humanities · 2021Article
- Article
- Risk of sexually transmitted infections following depressive disorder: A nationwide population-based cohort study.Medicine · 2018Article
- Sexually transmitted disease (STD) diagnoses and mental health disparities among women who have sex with women screened at an urban community health center, Boston, MA, 2007.Sexually transmitted diseases · 2010Article
- Role of social support in the relationship between sexually transmitted infection and depression among young women in Canada.Journal of epidemiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundA randomized controlled trial of SAFE, a cognitive/behavioral intervention, revealed that it significantly reduces reinfection and behavioral risks among participants compared with controls. However, studies suggest that depression may moderate intervention efficacy among affected persons because of impaired information processing, failure to recognize risk, or inability to change behavior. GOAL: We evaluated SAFE efficacy among depressed and nondepressed Mexican- and African American women after comparing initial risk factors by depression status. We further explored intervention effects in moderately and severely depressed women. STUDY
designWe stratified 477 participants (249 intervention, 228 controls) according to their depression status at baseline determined by CES-D scores. Using chi and multivariate logistic regression, we evaluated differences in reinfection and behavioral risk at 6-month, 12-month, and 1-year cumulative follow-ups between groups within baseline depression strata.
results: At baseline, 74.4% of women were depressed and had significantly greater levels of behavioral risks than nondepressed women. At follow-up intervals, behavioral risks and reinfection rates were lower among intervention women compared with controls regardless of depression status. For example, at 1-year follow-up reinfection rates were 15.2% in nondepressed intervention women versus 21.4% in nondepressed controls (AOR = 0.6), and 18.6% in depressed intervention women versus 27.3% in depressed controls (AOR = 0.6). Moreover, reinfection was consistently lower among moderately and severely depressed intervention women than controls (moderately depressed: 19.3% vs. 27.2%, AOR = 0.6; severely depressed: 17.9% vs. 27.5%, AOR = 0.6).
conclusionsDespite significantly greater behavioral risk among depressed women at baseline, SAFE was equally successful in reducing reinfection and high-risk behavior among depressed and nondepressed participants.
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