Evidence map›Paper›PMID 18606913›Full record

Trial reportCirculation2008

Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.

Arnt Erik Tjønna, Sang Jun Lee, Øivind Rognmo, Tomas O Stølen, Anja Bye, Per Magnus Haram, Jan Pål Loennechen, Qusai Y Al-Share, Eirik Skogvoll, Stig A Slørdahl and 3 more

6 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 449 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
449citing papers in PubMed, 28 pooled it
128.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355469 phase2 / phase3completedstarted 2017, after this paper: background citation

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Ran2017Enrolled91Registered outcomes6Posted comparisons36ConditionsMetabolic SyndromeArmsHigh intensity exercise, Low intensity exercise, Metformin, Placebo
PMID 26583801PMID 11300445PMID 22040838PMID 16115299PMID 23505172PMID 21947428PMID 21802577PMID 22961574PMID 21610226PMID 21200002PMID 21047922PMID 20338492other papers from this trial
Open the trial in the graph
NCT00218998 nacompletednot on this map

Effective Endurance Training in Metabolic Syndrome

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2004Enrolled30ConditionsImpaired Glucose Tolerance, Overweight, Hypertension, DyslipidemiaArmsexercise training
NCT01821313 nacompletednot on this mapstarted 2012, after this paper: background citation

Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity

TypeinterventionalSponsorNationwide Children's HospitalRan2012 to 2013Enrolled43ConditionsChildhood Obesity, InflammationArmsModerate exercise, High Intensity Interval Exercise
NCT02303470 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Vigorous Exercise Versus Moderate Exercise to Improve Glucose Metabolism and Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance: A Prospective Randomized Pilot Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2015 to 2025Enrolled47ConditionsPolycystic Ovary Syndrome, Insulin ResistanceArmsVigorous Exercise, Moderate Exercise
NCT03042234 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of High-intensity Interval Training on Cardiorespiratory Performance and Substrate Oxidation in Insulin-resistant and Insulin-sensitive Obese Adolescents: A Before-and-after Clinical Study

TypeinterventionalSponsorFaculdade de Ciências Médicas da Santa Casa de São PauloRan2017 to 2018Enrolled25ConditionsObesity, Insulin-resistant, AdolescentsArmsGroup Insulin-Resistant, Group Insulin-Sensitive
NCT03629613 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Effects of Oral Antioxidant Cocktail on Vascular Function and Blood Flow in Cardiovascular Disease Patients

TypeinterventionalSponsorUniversity of NebraskaRan2020 to 2022Enrolled0ConditionsCardiovascular DiseasesArmsOral antioxidant cocktail, Baseline
3 · Its place in the literature

Who cites it

449 citing papers in PubMed, 28 syntheses or guidelines pooled it, 1,122 citations in OpenAlex.

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  13. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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389 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Arnt Erik TjønnaDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Sang Jun Lee
Øivind Rognmo
Tomas O Stølen
Anja Bye
Per Magnus Haram
Jan Pål Loennechen
Qusai Y Al-Share
Eirik Skogvoll
Stig A Slørdahl
Ole J Kemi
Sonia M Najjar
Ulrik Wisløff
St Olav's University Hospital · NO

Funding

SUBSTRATES AND INSULIN RECEPTOR ENDOCYTOSISR01DK054254 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2000 to 2021
$5.8M
NIDDK NIH HHS DK 54254NIDDK NIH HHS R01 DK054254
6 · The paper itself

Abstract

backgroundIndividuals with the metabolic syndrome are 3 times more likely to die of heart disease than healthy counterparts. Exercise training reduces several of the symptoms of the syndrome, but the exercise intensity that yields the maximal beneficial adaptations is in dispute. We compared moderate and high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome. METHODS AND

resultsThirty-two metabolic syndrome patients (age, 52.3+/-3.7 years; maximal oxygen uptake [o(2)max], 34 mL x kg(-1) x min(-1)) were randomized to equal volumes of either moderate continuous moderate exercise (CME; 70% of highest measured heart rate [Hfmax]) or aerobic interval training (AIT; 90% of Hfmax) 3 times a week for 16 weeks or to a control group. o(2)max increased more after AIT than CME (35% versus 16%; P<0.01) and was associated with removal of more risk factors that constitute the metabolic syndrome (number of factors: AIT, 5.9 before versus 4.0 after; P<0.01; CME, 5.7 before versus 5.0 after; group difference, P<0.05). AIT was superior to CME in enhancing endothelial function (9% versus 5%; P<0.001), insulin signaling in fat and skeletal muscle, skeletal muscle biogenesis, and excitation-contraction coupling and in reducing blood glucose and lipogenesis in adipose tissue. The 2 exercise programs were equally effective at lowering mean arterial blood pressure and reducing body weight (-2.3 and -3.6 kg in AIT and CME, respectively) and fat.

conclusionsExercise intensity was an important factor for improving aerobic capacity and reversing the risk factors of the metabolic syndrome. These findings may have important implications for exercise training in rehabilitation programs and future studies.

Indexed as

AdultBody WeightCardiovascular DiseasesExercise TherapyFemaleHeart RateHumansMaleMetabolic SyndromeMetabolismMiddle AgedOxygen ConsumptionPilot Projects

Identifiers

PMID18606913
PMCPMC2777731
OpenAlexW2137206121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.